5-amino-1-cyclopropyl-6,8-difluoro-7-N-(4-methylpiperazin-1-yl)amino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-amino-1-cyclopropyl-6,8-difluoro-7-N-(4-methylpiperazin-1-yl)amino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 5-Amino-1-cyclopropyl-6,8-difluoro-7-[(4-methylpiperazin-1-yl)amino]-4-oxoquinoline-3-carboxylic acid
• 化学式: C₁₈H₂₁F₂N₅O₃
• 分子量: 393.393
• InChiKey: FYZWEDKGLMSTMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1-氨基-4-甲基哌嗪 、 5-氨基-1-环丙基-6,7,8-三氟-4-氧代-1,4-二氢-3-喹啉羧酸 以 吡啶 为溶剂， 反应 20.0h， 以9%的产率得到5-amino-1-cyclopropyl-6,8-difluoro-7-N-(4-methylpiperazin-1-yl)amino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and antibacterial activity of 7-hydrazinoquinolones

  摘要：

  A series of new C-7 substituted hydrazino quinolones and naphthyridines were prepared and tested for antibacterial activity. The hydrazine bridge at the C-7 position did not favor the antibacterial activity, whereas the nature of other substituents at N-1, C-5 and C-8 did noticeably influence the antibacterial activity. The 7-(1-aminomorpholino) derivatives exhibited superior antibacterial activity against Gram-positive and inferior activity against Gram-negative bacteria than the 7-(1-aminopiperazinyl) derivatives. Substitution of the quinolone at position-1 with cyclopropyl was the most beneficial for antibacterial activity among the series of compounds prepared. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80028-7

文献信息

• Synthesis and antibacterial activity of 7-hydrazinoquinolones
  作者：Rajeshwar Singh、Rakhshandeh Fathi-Afshar、George Thomas、Maya Prakash Singh、Fusahiro Higashitani、Akio Hyodo、Norio Unemi、Ronald George Micetich

  DOI：10.1016/s0223-5234(98)80028-7

  日期：1998.9

  A series of new C-7 substituted hydrazino quinolones and naphthyridines were prepared and tested for antibacterial activity. The hydrazine bridge at the C-7 position did not favor the antibacterial activity, whereas the nature of other substituents at N-1, C-5 and C-8 did noticeably influence the antibacterial activity. The 7-(1-aminomorpholino) derivatives exhibited superior antibacterial activity against Gram-positive and inferior activity against Gram-negative bacteria than the 7-(1-aminopiperazinyl) derivatives. Substitution of the quinolone at position-1 with cyclopropyl was the most beneficial for antibacterial activity among the series of compounds prepared. (C) Elsevier, Paris.