2-deoxy-β-D-arabino-hexopyranosyl-(1->4)-2-deoxy-D-arabino-hexose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-β-D-arabino-hexopyranosyl-(1->4)-2-deoxy-D-arabino-hexose
• 英文别名: 2-deoxy-D-araHex(b1-4)2-deoxy-D-araHex；(4R,5S,6R)-5-[(2S,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,4-diol
• 化学式: C₁₂H₂₂O₉
• 分子量: 310.301
• InChiKey: IKIMNPXVMZDSPX-OQEOTTNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-Deoxy-D-glucose 、 D-葡萄烯糖 在 cellobiose phosphorylase from Cellvibrio gilvus 、 MOPS buffer 作用下， 以 水 为溶剂， 反应 170.0h， 以59%的产率得到2-deoxy-β-D-arabino-hexopyranosyl-(1->4)-2-deoxy-D-arabino-hexose
  参考文献：
  名称：

  Reaction on d-glucal by an inverting phosphorylase to synthesize derivatives of 2-deoxy-β-d-arabino-hexopyranosyl-(1→4)-d-glucose (2II-deoxycellobiose)

  摘要：

  Four derivatives of 2(11)-deoxycellobiose were synthesized from D-glucal and acceptor sugars (D-glucose, D-xylose, D-mannose, and 2-deoxy-D-arabino-hexose) using a cellobiose phosphorylase from Cellvibrio gilvus. The enzyme was found to be an effective catalyst to synthesize the beta-(1 -> 4) linkage of 2-dcoxy-D-arabhio-hexopyranoside. The acceptor specificity for the D-glucal reaction was identical to that for the alpha-D-glucose 1-phosphate reaction, but the activity Of (D)-glucal was approximately 500 times less than that Of alpha-D-glucose 1-phosphate, using 10 mM substrates. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2006.01.003

文献信息

• Reaction on d-glucal by an inverting phosphorylase to synthesize derivatives of 2-deoxy-β-d-arabino-hexopyranosyl-(1→4)-d-glucose (2II-deoxycellobiose)
  作者：Motomitsu Kitaoka、Satoru Nomura、Michiteru Yoshida、Kiyoshi Hayashi

  DOI：10.1016/j.carres.2006.01.003

  日期：2006.3

  Four derivatives of 2(11)-deoxycellobiose were synthesized from D-glucal and acceptor sugars (D-glucose, D-xylose, D-mannose, and 2-deoxy-D-arabino-hexose) using a cellobiose phosphorylase from Cellvibrio gilvus. The enzyme was found to be an effective catalyst to synthesize the beta-(1 -> 4) linkage of 2-dcoxy-D-arabhio-hexopyranoside. The acceptor specificity for the D-glucal reaction was identical to that for the alpha-D-glucose 1-phosphate reaction, but the activity Of (D)-glucal was approximately 500 times less than that Of alpha-D-glucose 1-phosphate, using 10 mM substrates. (c) 2006 Elsevier Ltd. All rights reserved.