trans-1,1,1-Trifluorooctadec-3-en-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-1,1,1-Trifluorooctadec-3-en-2-one
• 英文别名: (E)-1,1,1-trifluorooctadec-3-en-2-one
• 化学式: C₁₈H₃₁F₃O
• 分子量: 320.439
• InChiKey: WLJOEHCBIZQZEN-FOCLMDBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-十六炔 在 lithium aluminium tetrahydride 、 正丁基锂 、 三氟化硼乙醚 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 11.0h， 生成 trans-1,1,1-Trifluorooctadec-3-en-2-one
  参考文献：
  名称：

  Synthesis of and Analysis of Thiol Additions to .beta.-Alkyl-.alpha.,.beta.-unsaturated Trifluoromethyl Ketones

  摘要：

  A series of beta-alkyl-alpha,beta-unsaturated trifluoromethyl ketones have been prepared from the corresponding alpha-acetylenic trifluoromethyl ketones. The addition of sulfur nucleophiles was shown by chemical and F-19 NMR studies to proceed exclusively by 1,4-addition with no indication of any 1,2-addition products. The unsaturated trifluoromethyl ketones have been shown to be effective inhibitors of rat cytosolic glutathione-S-transferase.

  DOI：

  10.1021/jo00084a009

文献信息

• [EN] OLEAMIDE IN EPILEPSY<br/>[FR] UTILISATION DE L'OLEAMIDE DANS LE TRAITEMENT DE L'EPILEPSIE
  申请人：UNIV SUNDERLAND

  公开号：WO2001035939A2

  公开（公告）日：2001-05-25

  There is described a method of treating a convulsant disorder which comprises altering the levels of oleamide in the brain of a patient suffering from such a disorder. The method may comprise altering the oleamide levels by administering a therapeutically effective amount of an amido hydrolase inhibitor, thus preventing the degradation of endogenous oleamide. Alternatively, the method may comprise administering a therapeutically effective amount of oleamide itself.
• Synthesis of and Analysis of Thiol Additions to .beta.-Alkyl-.alpha.,.beta.-unsaturated Trifluoromethyl Ketones
  作者：Russell J. Linderman、Eric A. Jamois、Scott D. Tennyson

  DOI：10.1021/jo00084a009

  日期：1994.3

  A series of beta-alkyl-alpha,beta-unsaturated trifluoromethyl ketones have been prepared from the corresponding alpha-acetylenic trifluoromethyl ketones. The addition of sulfur nucleophiles was shown by chemical and F-19 NMR studies to proceed exclusively by 1,4-addition with no indication of any 1,2-addition products. The unsaturated trifluoromethyl ketones have been shown to be effective inhibitors of rat cytosolic glutathione-S-transferase.