gluconolactone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: gluconolactone
• 英文别名: d-gluconolactone；glucono-lactone；Glucono-6-lactone；(3R,4S,5R,6R)-3,4,5,6-tetrahydroxyoxepan-2-one
• 化学式: C₆H₁₀O₆
• 分子量: 178.142
• InChiKey: WTXGYGWMPUGBAL-SQOUGZDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  gluconolactone 在 盐酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 D-gluconic acid thiosemicarbazide
  参考文献：
  名称：

  Precursors for the Synthesis of Substituted 1,3,4-Thiadiazolf, C-Nucleosides, Analogues of Tiazofurin and Related Compounds

  摘要：

  The synthesis of 2-substituted 1,3,4-thiadiazole C-glycosides is described by building a heterocyclic system at the aldehyde end of a series of sugar derivatives. Acid catalyzed dehydration of the polyhydroxylic chain resulted in C-nucleoside, an analogue of tiazofurin.

  DOI：

  10.1080/15257779408009483

文献信息

• [EN] PHENOTHIAZINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PHÉNOTHIAZINE ET LEURS UTILISATIONS
  申请人：CAMP4 THERAPEUTICS CORP

  公开号：WO2019195789A1

  公开（公告）日：2019-10-10

  The present invention provides phenothiazine compounds, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment of various diseases or conditions, for example ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA).

  本发明提供了吩噻嗪化合物，其制备方法，包含该化合物的药物组合物，以及在治疗各种疾病或症状中使用该化合物或组合物，例如核糖体紊乱和核糖体病，例如钻石-布莱克范贫血（DBA）。
• Method for manufacturing pigment dispersed liquid, and pigment dispersed liquid, and ink for ink-jet printer recording using said pigment dispersed liquid
  申请人：SEIKO EPSON CORPORATION

  公开号：US20020088375A1

  公开（公告）日：2002-07-11

  A method for manufacturing a pigment dispersed liquid, comprising at least: Step A of introducing a hydrophilic dispersibility-imparting group directly and/or via another atomic group to the surface of pigment particles; Step B of dispersing the pigment obtained in Step A in an aqueous medium; and Step C of conducting refining treatment of the dispersed liquid obtained in Step B.

  制造颜料分散液的方法，至少包括： 步骤A：将亲水性分散性赋予基团直接和/或通过另一个原子基团引入颜料颗粒的表面； 步骤B：将步骤A中获得的颜料分散在水性介质中； 步骤C：对步骤B中获得的分散液进行精炼处理。
• Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
  申请人：Eckhardt Matthias

  公开号：US20050209166A1

  公开（公告）日：2005-09-22

  Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  通用公式I的葡萄糖吡喃基取代苯衍生物，其中R1至R6基团以及R7a、R7b、R7c在此定义，并且其互变异构体、立体异构体、混合物及盐。根据本发明的化合物适用于治疗代谢紊乱。
• Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
  申请人：ECKHARDT Matthias

  公开号：US20070073046A1

  公开（公告）日：2007-03-29

  The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R 1 , R 2 and R 3 are defined according to claim 1 and to intermediates of said processes.

  本发明涉及制备一般式I化合物的过程，其中基团R1、R2和R3根据权利要求1定义，并涉及所述过程的中间体。
• Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
  申请人：Himmelsbach Frank

  公开号：US20070004648A1

  公开（公告）日：2007-01-04

  Glucopyranosyloxy-substituted benzyl-benzene derivatives of the general formula I where the groups groups R 1 , R 2 , R 3a , R 3b , R 4 , R 5 , R 6 , X and R 7a , R 7b , R 7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  根据权利要求1定义的通用公式I的葡萄糖吡喃氧基取代的苄基苯衍生物，包括基团R1、R2、R3a、R3b、R4、R5、R6、X以及R7a、R7b、R7c，包括互变异构体、立体异构体、它们的混合物以及它们的盐。根据发明的化合物适用于治疗代谢紊乱。