四异丙基锡 | 2949-42-0

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机锡
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 中文名称: 四异丙基锡
• 英文名称: tetraisopropyltin
• 英文别名: Tetraisopropylzinn；Tetraisopropyl-stannan；Tetra-i-propylzinn
• CAS: 2949-42-0
• 化学式: C₁₂H₂₈Sn
• 分子量: 291.064
• InChiKey: NJASUIDIZMMYED-UHFFFAOYSA-N

物化性质

• 沸点：
  89°C 10mm
• 密度：
  1,124 g/cm3
• 闪点：
  >38°C
• 暴露限值：
  ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3
• 保留指数：
  1327;1329;1339;1355
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  5.08
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• TSCA：
  No
• 危险等级：
  6.1
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090
• 包装等级：
  II
• 危险类别：
  6.1
• 危险品运输编号：
  UN2788
• 储存条件：
  存放于阴凉干燥处

SDS

---

Section 1: Product Identification
Chemical Name: Tetra-i-propyltin, min. 98%
CAS Registry Number: 2949-42-0
Formula: Sn(C3H7)4
EINECS Number: 220-969-5
Chemical Family: organotin compound
Synonym: Tetrakis(i-methylethyl)stannane

---

Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 2949-42-0 100% 0.1mg/m3 0.1mg/m3

---

Section 3: Hazards Identification
Irritating to skin, eyes and respiratory tract. Organo tin compounds may act as delayed poisons, causing
Emergency Overview:
headache, psycho-neurologic disturbances, vision impairment; skin burns, liver and kidney damage.
Primary Routes of Exposure: Ingestion, inhalation, skin, eyes
Eye Contact: Causes severe irritation of the eyes.
Causes slight to mild irritation of the skin. Prolonged contact may dry the skin and lead to rashes or more
Skin Contact:
severe irritation.
Irritating to the nose, mucous membranes and respiratory tract. High doses may cause long term neurological
Inhalation:
damage.
Delayed and permanent psycho-neurologic disturbances; impairment of vision, unsteadiness, nausea and
Ingestion:
vomiting.
Irritating to skin, eyes and mucous membranes. Ingestion of certain organotin compounds may cause delayed
Acute Health Affects:
poisoning (4 days) with cerebral edema causing damage to the central nervous system.
Repeated exposure to certain organic tin compounds may cause problems with vision, skin, respiratory
Chronic Health Affects:
system, central nervous system, liver, kidneys, urinary tract, and blood .
NTP: No
IARC: No
OSHA: No

---

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

---

SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide, foam or dry powder
Fire fighters should be equipped with a NIOSH approved positive pressure self-contained breathing apparatus
Special Fire Fighting Procedures:
and full protective clothing.
Hazardous Combustion and carbon monoxide, carbon dioxide, soot, organic fumes and tin compounds.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

---

SECTION 6: Accidental Release Measures
Small spills can be mixed with vermiculite, ground limestone, sodium carbonate or other suitable
Spill and Leak Procedures:
noncombustible adsorbent and swept up.

---

SECTION 7: Handling and Storage
Handling and Storage: Store in a cool, dry, well ventilated area away from heat and direct sunlight. Keep containers tightly sealed.

---

SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation: Work with this product in a well-ventilated area, preferably a fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Work with this product in a well-ventilated area, preferably a fume hood.
Additional Protection: No additional protection required.

---

SECTION 9: Physical and Chemical Properties
Color and Form: colorless liq.
Molecular Weight: 291.05
Melting Point: no data
Boiling Point: 112-114°C /18 mm
Vapor Pressure: no data
Specific Gravity: no data
Odor: not determined
Solubility in Water: insoluble

---

SECTION 10: Stability and Reactivity
Stability: air and moisture stable
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: none
Incompatibility: strong oxidizing agents and halogens
Decomposition Products: carbon monoxide, carbon dioxide, tin oxide, and organic fumes.

---

SECTION 11: Toxicological Information
RTECS Data: Intravenous (mouse); LD50: 56 mg/kg.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

---

SECTION 12: Ecological Information
Ecological Information: No information available

---

SECTION 13: Disposal Considerations
Disposal: Dispose of according to federal, state, and local regulations.

---

SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

---

SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  四异丙基锡 在 CCl₄ 作用下， 生成 三-I-丙基氯化锡
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sn: Org.Verb.1, 1.1.1.4.3, page 92 - 93

  摘要：

  DOI：
• 作为产物：
  描述：

  异丙基氯化镁 在 四氯化锡 、 xylene 作用下， 生成 四异丙基锡
  参考文献：
  名称：

  CAUJOLLE; LESBRE; MEYNIER, Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1955, vol. 240, # 17, p. 1732 - 1734

  摘要：

  DOI：
• 作为试剂：
  描述：

  5-内酯 在 sodium methylate 、 四异丙基锡 、 三氧化硫吡啶 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 正庚烷 、 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 41.0h， 生成 (2R,3S,4S,5R,6R)-2,3,4-tribenzyloxy-5-(benzyloxymethyl)-5,6-dihydroxy-1-(4-tritylpiperazin-1-yl)heptan-1-one
  参考文献：
  名称：

  [EN] METHOD FOR PREPARING GLUCOPYRANOSYL DERIVATIVES AND INTERMEDIATES THEREOF
  [FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE GLUCOPYRANOSYLE ET INTERMÉDIAIRES DE CEUX-CI

  摘要：

  一种制备葡萄糖吡喃基衍生物作为钠依赖型葡萄糖共转运蛋白（SGLT）抑制剂的方法，其中间体，以及制备该中间体的方法。该方法操作简单，后处理简单，易于纯化，总产率高，产品光学纯度高，过程安全可控，适合工业生产。

  公开号：

  WO2022007838A1

文献信息

• Transition Metal-Free Direct Hydrogenation of Esters via a Frustrated Lewis Pair
  作者：Joshua S. Sapsford、Dániel Csókás、Roland C. Turnell-Ritson、Liam A. Parkin、Andrew D. Crawford、Imre Pápai、Andrew E. Ashley

  DOI：10.1021/acscatal.1c01940

  日期：2021.8.6

  “Frustrated Lewis pairs” (FLPs) continue to exhibit unique reactivity for the reduction of organic substrates, yet to date, the catalytic hydrogenation of an ester functionality has not been demonstrated. Here, we report that iPr3SnNTf2 (1-NTf2; Tf = SO2CF3) is a more potent Lewis acid than the previously studied iPr3SnOTf; in an FLP with 2,4,6-collidine/2,6-lutidine (col/lut), this translates to faster

  “受挫的路易斯对”（FLP）继续表现出独特的还原有机底物的反应性，但迄今为止，酯官能团的催化氢化尚未得到证实。在这里，我们报告了 iPr 3 SnNTf 2 ( 1 -NTf 2 ; Tf = SO 2 CF 3 ) 是比之前研究的 iPr 3 SnOTf更有效的路易斯酸；在具有 2,4,6-可力丁/2,6-二甲基吡啶 (col/lut) 的 FLP 中，这转化为更快的 H 2活化和酯键的催化氢解通过主基团化合物，提供醇和醚（次要）产品。反应结果对底物的空间和电子特性很敏感；CF3 CO 2 Et 和简单的甲酸酯（HCO 2 Me 和 HCO 2 Et）被催化还原，而相关的酯 CF 3 CO 2 n Bu 和 CH 3 CO 2 Et 仅显示化学计量反应性。CF 3 CO 2 Et 和 CH 3 CO 2 Et加氢的计算案例研究表明，两者具有共同的机理途径；然而，出现了 Sn-缩醛中间态和过渡态能量的关键差异，有利于
• [EN] REACTIONS OF STANNYL CATIONS<br/>[FR] RÉACTIONS DE CATIONS STANNYLE
  申请人：IMPERIAL INNOVATIONS LTD

  公开号：WO2017212289A1

  公开（公告）日：2017-12-14

  The present invention relates to a method of reducing, cleaving and/or coupling at least one C=O, C-O, C=C or C=N bond of a compound, using a reagent comprising a stannyl cation.

  本发明涉及一种利用含有锡阳离子的试剂来减少、裂解和/或偶联化合物中至少一个C=O、C-O、C=C或C=N键的方法。
• Substitution at saturated carbon. Part XIII. Steric effects in the substitution of tetra-alkyltin compounds by mercury(II) chloride in t-butyl alcohol and in acetonitrile
  作者：M. H. Abraham、F. Behbahany、M. J. Hogarth

  DOI：10.1039/j19710002566

  日期：——

  previously for the substitution of tetra-alkyltins by mercury(II) chloride in methanol and methanol–water mixtures. It is concluded that the above substitutions in solvents t-butyl alcohol and acetonitrile proceed by essentially the same mechanism as do the corresponding substitutions in solvents methanol and methanol–water, that is by the SE2(open) mechanism of substitution at saturated carbon.

  已确定了在溶剂叔丁醇和乙腈中用氯化汞（II）取代四甲基，四乙基，四正丙基，四异丙基，四正丁基和四异丁基锡的速率常数。。对于这两种溶剂，速率常数沿R 4 Sn = Me 4 Sn Et 4 Sn> Pr n 4 Sn Bu n 4 Sn> Bu i 4 Sn Pr i 4 Sn序列显着降低，因此产生相同的空间顺序以前发现的被汞取代四烷基锡的反应性（II）在甲醇和甲醇-水混合物中的氯化物。结论是，上述在叔丁醇和乙腈溶剂中的取代基本上是通过与在溶剂甲醇和甲醇-水中的相应取代相同的机理进行的，即通过在饱和碳原子上的S E 2（open）取代机理进行的。 。
• Substitution at saturated carbon. Part V. The bimolecular electrophilic substitution of several tetra-alkyltins by mercuric chloride in methanol–water mixtures. Kinetics, mechanism, and activation parameters
  作者：M. H. Abraham、G. F. Johnston

  DOI：10.1039/j19700000193

  日期：——

  coefficients and activation parameters are reported for the substitution of tetramethyl-, tetra-n-propyl-, tetra-n-butyl-, and tetraisobutyl-tin by mercuric chloride in methanol–water mixtures of mole fraction methanol 1, 0·91, and 0·72. In addition, an upper limit can be set for the rate coefficient for substitution of tetraisopropyltin by mercuric chloride. The rate coefficients decrease in value markedly

  据报道，在摩尔分数为1，0的甲醇-甲醇混合物中，氯化汞可以用氯化汞取代四甲基，四正丙基，四正丁基和四异丁基锡的二阶速率系数和活化参数。 ·91和0·72。另外，可以设定氯化汞取代四异丙基锡的速率系数的上限。速率系数的值沿序列R 4 Sn = Me 4 Sn Et 4 Sn> Pr n 4 Sn Bu n 4 Sn> Bu i 4 Sn Pr i 4显着减小用锡替代三种使用的溶剂混合物。尽管随着溶剂中水含量的增加，任何给定的四烷基锡的取代率系数都显着增加，但是与取代四甲基锡的比率相比，相对速率系数几乎不受溶剂组成变化的影响。结论是，在所使用的三种溶剂混合物中，氯化汞对四烷基锡的取代是通过饱和碳上亲电取代的S E 2（open）机理，通过已经发生大量电荷分离的过渡态进行的。
• Thyroid receptor ligands and method
  申请人：Karo Bio AB

  公开号：US06465687B1

  公开（公告）日：2002-10-15

  Novel thyroid receptor ligands are provided which have the general formula (I) where R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; n is an integer from 0 to 4; R4 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, cyano, or a phosphonic acid or an ester thereof, or a pharmaceutically acceptible salt thereof. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a T3 regulated gene, such as obesity, hypercholesterolemia, osteoporosis, hypothyroidism, and goiter, is also provided.

  提供了具有一般式(I)的新型甲状腺受体配体 其中R1是1至4个碳原子的烷基或3至7个碳原子的环烷基；R2和R3相同或不同，是氢、卤素、1至3个碳原子的烷基或3至5个碳原子的环烷基，R2和R3中至少有一个不是氢；n是从0到4的整数；R4是脂肪烃、芳香烃、羧酸酯、烯基羧酸或其酯、羟基、卤素、氰基、磷酸或其酯，或其药用可接受盐。还提供了一种治疗与代谢功能障碍或依赖T3调节基因表达的疾病有关的方法，如肥胖症、高胆固醇血症、骨质疏松症、甲状腺功能减退症和甲状腺肿。

表征谱图