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methyl 7-((2R)-2-((3R,4R/S,1E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

中文名称
——
中文别名
——
英文名称
methyl 7-((2R)-2-((3R,4R/S,1E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoate
英文别名
methyl 7-((2R)-2-((3R,4R/S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoate;methyl 7-((2R)-2-((3R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoate;methyl 7-[(2R)-2-[(E,3R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-5-oxopyrrolidin-1-yl]heptanoate
methyl 7-((2R)-2-((3R,4R/S,1E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoate化学式
CAS
——
化学式
C21H33NO4
mdl
——
分子量
363.497
InChiKey
FCFQGZGDLMMISZ-PFCRAWMCSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.8
  • 重原子数:
    26
  • 可旋转键数:
    12
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.71
  • 拓扑面积:
    66.8
  • 氢给体数:
    1
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

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文献信息

  • LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS
    申请人:CAYMAN CHEMICAL COMPANY, INC.
    公开号:US20160060216A1
    公开(公告)日:2016-03-03
    Disclosed herein are compounds of formula (I) wherein L 1 , L 2 , L 3 , L 4 , R 1 , R 4 , R 5 , R 6 , and s are as defined in the specification. Compounds of formula (I) are EP 4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
    披露了公式(I)的化合物 其中L 1 , L 2 , L 3 , L 4 , R 1 , R 4 , R 5 , R 6 ,和s如说明书所定义。 公式(I)的化合物是EP 4 激动剂,用于治疗青光眼、骨质疏松症、骨折、牙周骨丢失、矫形植入物、脱发、神经性疼痛和相关的疾病。 还描述了药物组合物和治疗条件或疾病的方法。
  • EP4-매개 질환 및 병태의 치료에서 사용하기 위한 EP4 수용체 선택적 효현제로서 락탐 화합물
    申请人:CAYMAN CHEMICAL COMPANY, INCORPORATED 카이맨 케미칼 컴파니 인코포레이티드(520110169899)
    公开号:KR20150130326A
    公开(公告)日:2015-11-23
    화학식 I의 화합물(식 중, L, L, L, L, R, R, R, R 및 s는 본 명세서에 정의된 바와 같음)이 본 명세서에 개시되어 있다. 화학식 I의 화합물은 녹내장, 골다공증, 골절, 치주 골손실, 정형외과적 이식, 탈모, 신경병증성 통증 및 관련 장애의 치료에서 유용한 EP 효현제이다. 약제학적 조성물 및 병태 또는 장애를 치료하는 방법이 또한 기재되어 있다. [화학식 I]
    化学式 I 的化合物(式中,L、L、L、L、R、R、R、R 以及 s 如本文所述)在本说明书中有所披露。化学式 I 的化合物是一种有用的 EP 表现型药剂,用于治疗青光眼、骨质疏松症、骨折、牙周骨丢失、整形外科移植、脱发、神经性疼痛及相关疾病。药物化学组成以及治疗病态或疾病的方法也有所记载。[化学式 I]
  • METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH
    申请人:CAYMAN CHEMICAL COMPANY, INC.
    公开号:US20160158413A1
    公开(公告)日:2016-06-09
    The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.
    本发明涉及一种新型骨组成物,用于局部向骨缺损部位提供治疗剂。治疗剂可以促进骨缺损的修复和/或治疗疼痛、炎症、癌症和感染等病症或疾病。该组成物包括磷酸钙水泥和脱矿骨基质或胶原海绵。该组成物可用于患者的骨缺损部位植入。
  • Methods, systems, and compositions for promoting bone growth
    申请人:Cayman Chemical Company, Inc.
    公开号:US10729810B2
    公开(公告)日:2020-08-04
    The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.
    本发明涉及用于向骨缺损部位局部输送治疗剂的新型骨组合物。治疗剂可促进骨缺损的修复和/或治疗疼痛、炎症、癌症和感染等疾病。组合物包括磷酸钙骨水泥和脱矿骨基质或胶原海绵。这些组合物可用于植入患者骨缺损部位。
  • US9688627B2
    申请人:——
    公开号:US9688627B2
    公开(公告)日:2017-06-27
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