1,3-bis-(4-methoxymethylphenyl)-propan-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-bis-(4-methoxymethylphenyl)-propan-2-one
• 英文别名: 1,3-Bis[4-(methoxymethyl)phenyl]propan-2-one；1,3-bis[4-(methoxymethyl)phenyl]propan-2-one
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: UATQQCTYQXPYON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对苯二甲醇 在 N-溴代丁二酰亚胺(NBS) 、 二甲基硫 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 1,3-bis-(4-methoxymethylphenyl)-propan-2-one
  参考文献：
  名称：

  Synthesis of Heterosubstituted Hexaarylbenzenes via Asymmetric Carbonylative Couplings of Benzyl Halides

  摘要：

  Asymmetric carbonylative couplings of benzyl halides have been shown to give heterosubstituted 1,3-diarylacetones in moderate to high yields. These asymmetric ketones were converted via Knoevenagel condensations to tetraarylcyclopentadienones, and further conversion via dehydro-Diels-Alder cycloadditions gave highly heterofunctionalized hexaarylbenzenes with uniquely functionalized aryl groups at the para positions of the central benzene. This method allows control of the substituents on each of four unique pendent aryl group positions, giving rise to substitution patterns not available using symmetrical 1,3-diarylacetones.

  DOI：

  10.1021/ol0629770

文献信息

• Synthetic Carbon Nanotubes
  申请人：Hua Duy H.

  公开号：US20100222432A1

  公开（公告）日：2010-09-02

  Methods to prepare synthetic carbon nanotubes having controllable properties and synthetic carbon nanotubes having controllable properties are provided. The properties which are controllable using the methods provided here include independently and in combination: diameter, length, identity and number of functional groups present and identity and number of heteroatoms present.

  提供了制备具有可控性质的人工碳纳米管的方法和具有可控性质的人工碳纳米管。使用此处提供的方法可控制的性质包括：直径、长度、存在的官能团的种类和数量、存在的杂原子的种类和数量，这些性质可以独立或组合进行控制。
• Synthesis of Heterosubstituted Hexaarylbenzenes via Asymmetric Carbonylative Couplings of Benzyl Halides
  作者：Robert G. Potter、Thomas S. Hughes

  DOI：10.1021/ol0629770

  日期：2007.3.1

  Asymmetric carbonylative couplings of benzyl halides have been shown to give heterosubstituted 1,3-diarylacetones in moderate to high yields. These asymmetric ketones were converted via Knoevenagel condensations to tetraarylcyclopentadienones, and further conversion via dehydro-Diels-Alder cycloadditions gave highly heterofunctionalized hexaarylbenzenes with uniquely functionalized aryl groups at the para positions of the central benzene. This method allows control of the substituents on each of four unique pendent aryl group positions, giving rise to substitution patterns not available using symmetrical 1,3-diarylacetones.