COMPOSITION COMPRISING A METAL SALT OF NEODECANOIC ACID
申请人:Bostik SA
公开号:EP3696222A1
公开(公告)日:2020-08-19
The present invention concerns a curable composition, preferably a moisture-curable composition, comprising:
a) at least one silane-functional polymer P; and
b) at least one metal salt of neodecanoic acid wherein the metal salt is chosen from the group consisting of alkali metal salts and alkali earth metal salts.
本发明涉及一种固化组合物,最好是一种湿气固化组合物,包括
a) 至少一种硅烷功能聚合物 P;和
b) 至少一种新癸酸金属盐,其中金属盐选自碱金属盐和碱土金属盐组成的组。
NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS
申请人:Beusker Patrick Henry
公开号:US20130224227A1
公开(公告)日:2013-08-29
This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
申请人:SYNTARGA BV
公开号:US20170274090A1
公开(公告)日:2017-09-28
This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
US9629924B2
申请人:——
公开号:US9629924B2
公开(公告)日:2017-04-25
Ligand-Enabled Monoselective β-C(sp<sup>3</sup>)–H Acyloxylation of Free Carboxylic Acids Using a Practical Oxidant
作者:Zhe Zhuang、Alastair N. Herron、Zhoulong Fan、Jin-Quan Yu
DOI:10.1021/jacs.0c01214
日期:2020.4.8
recent disclosure of the β-lactonization of free aliphatic acids, the use of peroxides in C-H activation reactions directed by weakly coordinating native functional groups was unreported. Herein we report C(sp3)-H β-acetoxylation and γ-, δ-, and ε-lactonization reactions of freecarboxylicacids enabled by a novel cyclopentane-based mono-N-protected β-amino acid (MPAA) ligand. Notably, tert-butyl hydrogen