4-(pyridin-4-yl)thiazole-2-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(pyridin-4-yl)thiazole-2-carbaldehyde
• 英文别名: 4-(Pyridin-4-yl)thiazole2-carbaldehyde；4-pyridin-4-yl-1,3-thiazole-2-carbaldehyde
• 化学式: C₉H₆N₂OS
• 分子量: 190.225
• InChiKey: ZCKUEMQGPPIXNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(pyridin-4-yl)thiazole-2-carbaldehyde 在 哌啶 、 吡啶 、 盐酸羟胺 作用下， 以 乙醇 、 异丙醇 为溶剂， 反应 18.0h， 生成 4-{2-[3-(4-nitrophenyl)isoxazol-5-yl]thiazol-4-yl}pyridine
  参考文献：
  名称：

  Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives

  摘要：

  A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by H-1 and C-13 NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.

  DOI：

  10.1134/s1070363219120314
• 作为产物：
  描述：

  4-(溴乙酰基)吡啶氢溴酸盐 在 二异丁基氢化铝 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 为溶剂， 反应 5.0h， 生成 4-(pyridin-4-yl)thiazole-2-carbaldehyde
  参考文献：
  名称：

  Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives

  摘要：

  A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by H-1 and C-13 NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.

  DOI：

  10.1134/s1070363219120314

文献信息

• TRICYCLIC CARBAPENEM COMPOUNDS
  申请人：GLAXO WELLCOME S.p.A.

  公开号：EP0937078A1

  公开（公告）日：1999-08-25
• US6239108B1
  申请人：——

  公开号：US6239108B1

  公开（公告）日：2001-05-29
• US6531466B2
  申请人：——

  公开号：US6531466B2

  公开（公告）日：2003-03-11
• [EN] TRICYCLIC CARBAPENEM COMPOUNDS<br/>[FR] COMPOSES CARBAPENEM
  申请人：GLAXO WELLCOME S.P.A.

  公开号：WO1998021210A1

  公开（公告）日：1998-05-22

  (EN) A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of 3 members one of which is selected from an oxygen or sulphur atom or the group NH or a substituted derivative thereof and the other two members are methylene groups, having antibacterial activity, processes for their preparation and to their use in medicine.(FR) L'invention concerne un composé de la formule (I), des sels et des esters métaboliquement labiles dudit composé ayant une activité antibactérienne, ainsi que des procédés pour leur préparation et leur utilisation en médecine. Dans la formule, R représente un aryle éventuellement substitué ou un groupe hétéroaryle; A représente une chaîne propylène ou est une chaîne constituée de 3 éléments, dont l'un appartient au groupe constitué d'un atome d'oxygène, d'un atome de soufre, du groupe NH ou d'un dérivé substitué du groupe, les deux autres éléments étant des groupes méthylènes.
• Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Likned Thiazole-1,2-isoxazole Derivatives
  作者：T. Yakantham、R. Sreenivasulu、G. Alluraiah、M. B. Tej、R. Ramesh Raju

  DOI：10.1134/s1070363219120314

  日期：2019.12

  A series of novel 1,2,3-triazole linked thiazole-1,2-isoxazole derivatives has been designed, synthesized and characterized by H-1 and C-13 NMR, and mass spectral analysis. The compounds have been tested for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) by using the MTT method using etoposide as the reference. Most of the tested compounds demonstrate good to moderate activity against all cell lines. The compounds 14b, 14e, 14g, and 14h are characterized by inhibitory activity stronger than that of etoposide.