(2E)-1-(2,5-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-ene-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2E)-1-(2,5-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-ene-1-one
• 英文别名: (E)-1-(2,5-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one；3.4.2'.5'-tetrahydroxy-trans-chalcone；3.4.2'.5'-Tetrahydroxy-trans-chalkon；3,4,2',5'-tetrahydroxychalcone；3-(3,4-Dihydroxy-phenyl)-1-(2,5-dihydroxy-phenyl)-propenone
• 化学式: C₁₅H₁₂O₅
• 分子量: 272.257
• InChiKey: PFOGPGPNRKORCH-DAFODLJHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-二(四氢吡喃-2-氧基)苯甲醛 在 barium dihydroxide 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 23.0h， 生成 (2E)-1-(2,5-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-ene-1-one
  参考文献：
  名称：

  3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors

  摘要：

  A novel series of 3,4-dihydroxychalcones was synthesized to evaluate their effects against 5-lipoxygenase and cyclooxygenase. Almost all compounds exhibited potent inhibitory effects on 5-lipoxygenase with antioxidative effects, and some also inhibited cyclooxygenase. The 2',5'-disubstituted 3,4-dihydroxychalcones with hydroxy or alkoxy groups exhibited optimal inhibition of cyclooxygenase. We found that 2',5'-dimethoxy-3,4-dihydroxychalcone (37; HX-0836) inhibited cyclooxygenase to the same degree as flufenamic acid and 6-lipoxygenase, more than quercetin. Finally, these active inhibitors of 5-lipoxygenase inhibited arachidonic acid-induced mouse ear edema more than phenidone.

  DOI：

  10.1021/jm00076a019

文献信息

• Remedies
  申请人：——

  公开号：US20030144316A1

  公开（公告）日：2003-07-31

  The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

  本发明提供了一种治疗剂或预防剂，用于需要增强神经生长因子产生的疾病，用于增强神经生长因子产生的增强剂，或用作增强神经生长因子产生的食品、饮料或饲料，每种包含一种有效成分，即具有增强神经生长因子产生活性的指定化合物或其盐；一种增强神经生长因子产生的方法，包括向哺乳动物投与上述化合物或其盐；以及使用上述化合物或其盐制备需要增强神经生长因子产生的疾病的治疗剂或预防剂，增强神经生长因子产生的增强剂，或用于增强神经生长因子产生的食品、饮料或饲料。此外，本发明提供了具有增强神经生长因子产生活性的新化合物。
• Therapeutic agent
  申请人：Enoki Tatsuji

  公开号：US20070092551A1

  公开（公告）日：2007-04-26

  A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

  一种治疗伴随胰岛素或胰岛素反应异常的疾病的治疗剂和预防剂，一种具有类胰岛素作用的剂，一种食品、饮料和饲料，一种增强葡萄糖进入细胞的剂，以及一种诱导分化成脂肪细胞的剂，其特征在于每种剂都包含至少一种有效成分，所述有效成分选自香豆素类化合物、苯乙酮类化合物、香豆酮类化合物、邻苯二甲酸酯类化合物及其衍生物和药学上可接受的盐。
• REMEDIES
  申请人：TAKARA BIO INC.

  公开号：EP1254658A1

  公开（公告）日：2002-11-06

  The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

  本发明提供了一种用于需要增强神经生长因子产生的疾病的治疗剂或预防剂，一种用于增强神经生长因子产生的增强剂，或一种用于增强神经生长因子产生的食品、饮料或饲料，每一种都包含作为有效成分的具有增强神经生长因子产生活性的特定化合物或其盐；一种增强神经生长因子生成的方法，包括向哺乳动物施用上述化合物或其盐；以及上述化合物或其盐在制备需要增强神经生长因子生成的疾病的治疗剂或预防剂、神经生长因子生成增强剂或增强神经生长因子生成的食品、饮料或饲料中的用途。此外，本发明还提供了具有增强神经生长因子生成活性的新型化合物。
• EP1623704
  申请人：——

  公开号：——

  公开（公告）日：——
• Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor
  作者：Mayumi Hotsumi、Misato Tajiri、Yuri Nikaido、Taki Sato、Koki Makabe、Hiroyuki Konno

  DOI：10.1016/j.bmcl.2019.06.052

  日期：2019.8

  A structure activity relationship study of curcumin analogues for the inhibition of amyloid beta aggregation is described. Optimization of the o-phenol and olefin spacer resulted in the identification of the C5-monoketone type curcumin analogue AY1319, which exhibited potent anti-amyloid beta aggregation activity (leading to nanorod-like fragments), sufficient water solubility, and low cytotoxicity.