申请人：Yamada Rintaro
公开号：US20060247266A1
公开（公告）日：2006-11-02
A novel compound represented by the following formula (1) or a salt thereof [wherein R
1
, R
5
, R
6
, R
7
, and R
8
represent hydrogen atom, a halogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like; X
1
. . . X
2
represents —CH(R
2
)—CH(R
3
)—, —CH(R
2
)—CH(R
3
)—CH(R
4
)—, —C(R
2
)═C(R
3
)—, or —C(R
2
)═C(R
3
)—CH(R
4
)—(R
2
, R
3
, and R
4
represent hydrogen atom, or an alkyl group); A
1
, A
11
, A
2
, and A
21
represent hydrogen atom, or an alkyl group; Y represents —CH(A
3
)-, —CH(A
3
)-C(A
4
)(A
41
)-, —CH(A
3
)-C(A
4
)(A
41
)-C(A
5
)(A
51
)-, or a single bond (A
3
, A
4
, A
41
, A
5
, and A
51
represent hydrogen atom, or an alkyl group), and Z represents hydroxyl group, or —N(A
6
)(A
61
)(A
6
represents hydrogen atom, or an alkyl group, and A
61
represents hydrogen atom, an alkyl group, a substituted alkyl group and the like)], having an action of potently inhibiting phosphorylation of myosin regulatory light chain.
以下式（1）表示的新化合物或其盐[其中R1、R5、R6、R7和R8代表氢原子、卤素原子、羟基、烷基、烯基等；X1...X2代表—CH(R2)—CH(R3)—、—CH(R2)—CH(R3)—CH(R4)—、—C(R2)=C(R3)—或—C(R2)=C(R3)—CH(R4)—(R2、R3和R4代表氢原子或烷基)；A1、A11、A2和A21代表氢原子或烷基；Y代表—CH(A3)-、—CH(A3)-C(A4)(A41)-、—CH(A3)-C(A4)(A41)-C(A5)(A51)-或单一键（A3、A4、A41、A5和A51代表氢原子或烷基），Z代表羟基或—N(A6)(A61)(A6代表氢原子或烷基，A61代表氢原子、烷基、取代烷基等)]具有强烈抑制肌球蛋白调节轻链磷酸化的作用。
