地喹氯铵

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 地喹氯铵
• 中文别名: 喹氯铵；克菌定；地喹氯胺
• 英文名称: 1-[10-(4-Imino-2-methylquinolin-1-yl)decyl]-2-methylquinolin-4-imine;dihydrochloride
• 英文别名: 1-[10-(4-imino-2-methylquinolin-1-yl)decyl]-2-methylquinolin-4-imine;dihydrochloride
• 化学式: C30H40Cl2N4
• mdl: MFCD00063502
• 分子量: 527.6
• InChiKey: LTNZEXKYNRNOGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.59
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  59.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  地喹氯铵 生成 β-环糊精
  参考文献：
  名称：

  TAKASIMA, JODZI;KAVAMATA, ITIRO;KADOTA, KEHNDZI;KIMURA, MITIKO;MURAYAMA, +

  摘要：

  DOI：
• 作为产物：
  描述：

  β-环糊精 生成 地喹氯铵
  参考文献：
  名称：

  TAKASIMA, JODZI;KAVAMATA, ITIRO;KADOTA, KEHNDZI;KIMURA, MITIKO;MURAYAMA, +

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS<br/>[FR] COMPOSÉS AROMATIQUES SUBSTITUÉS ET PROCÉDÉ ASSOCIÉ POUR LE TRAITEMENT DE LA FIBROSE
  申请人：PROMETIC BIOSCIENCES INC

  公开号：WO2014138906A1

  公开（公告）日：2014-09-18

  The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1 ) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.

  本发明涉及以下化合物的制备：或其药用盐，其中A为C5烷基、C6烷基、C5烯基、C6烯基、C(0)-(CH2)n-CH3或CH(OH)-(CH2)n-CH3，其中n为3或4；R1为H、F或OH；R2为C5烷基、C6烷基、C5烯基、C6烯基、C(0)-(CH2)n-CH3或CH(OH)-(CH2)n-CH3，其中n为3或4；R3为H、F、OH或CH2Ph；R4为H、F或OH；Q为1）（CH2）mC(0)OH，其中m为1或2，2）CH(CH3)C(0)OH，3）C(CH3)2C(0)OH，4）CH(F)-C(0)OH，5）CF2-C(0)OH，或6）C(0)-C(0)OH；以及包含该化合物的组合物和使用该化合物预防或治疗受试者各种纤维化疾病和状况的方法，包括肺纤维化、肝纤维化、皮肤纤维化、肾纤维化、胰腺纤维化、系统性硬化病、心肌纤维化或黄斑变性。
• [EN] TYPE 4 PREPILIN PEPTIDASE INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DE LA PRÉPILINE PEPTIDASE DE TYPE 4 ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：DARTMOUTH COLLEGE

  公开号：WO2015123130A1

  公开（公告）日：2015-08-20

  Compounds for inhibiting Type 4 Prepilin Peptidases are provided as are methods of using the compounds as anti-bacterial agents.

  抑制Type 4前体肽酶的化合物及其作为抗细菌剂的用途方法。
• BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
  申请人：Dietz Ulrich

  公开号：US20140099354A1

  公开（公告）日：2014-04-10

  The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.

  本发明涉及一种含硝基羧酸（s）的磷脂，用于涂覆医疗器械，如支架、导管球囊、伤口垫或外科缝合材料，以及用于生物钝化组合物，如漱口液、防水溶液、涂层溶液、冷冻保护溶液、冷藏介质、冻干保护溶液、造影介质溶液、含有这些化合物的保存和再灌注溶液，以及制备这些溶液和涂覆医疗器械以及它们的用途。
• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
  申请人：SLIL Biomedical Corporation

  公开号：US20030195377A1

  公开（公告）日：2003-10-16

  Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

  抑制构象限制的多胺化合物可用于治疗癌症和其他以异常细胞增殖为特征的疾病。改进的合成这类化合物的方法也被揭示。在该发明的一种方法中，带有卡宾基或卡宾等效基团的化合物与烯烃化合物的双键发生反应，形成环丙基环作为合成的第一步。

表征谱图