4-(3,4-dichlorophenyl)-2-phenyl-2H-[1,2,3]triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(3,4-dichlorophenyl)-2-phenyl-2H-[1,2,3]triazole
• 英文别名: 4-(3,4-Dichlorophenyl)-2-phenyltriazole
• 化学式: C₁₄H₉Cl₂N₃
• 分子量: 290.152
• InChiKey: WEPKDUQHBZWJMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-3',4'-二氯苯乙酮 、 苯肼 在 溶剂黄146 、 copper dichloride 作用下， 反应 2.0h， 以39%的产率得到4-(3,4-dichlorophenyl)-2-phenyl-2H-[1,2,3]triazole
  参考文献：
  名称：

  Another Way to the Synthesis of 1,2,3-Triazoles

  摘要：

  The reactions of α‐bromoacetophenones with methylhydrazine in refluxing acetic acid generated 2‐methyl‐4‐aryl‐2H‐[1,2,3]triazoles in good yields. The method was developed by the reactions of α‐bromoacetophenones with phenylhydrazines in the presence of cupric ion, leading to 2,4‐diary‐2H‐[1,2,3]triazoles. The structures were established on the basis of corresponding IR, 1H NMR, and elemental analysis data.

  DOI：

  10.1002/jhet.1095

文献信息

• A Novel and Efficient Strategy for the Preparation of 2,4-Disubstituted-1,2,3-triazoles
  作者：Yun Luo、Yongzhou Hu

  DOI：10.1081/scc-120024731

  日期：2003.10

  Abstract We have developed a novel and efficient method for the preparation of 2,4-disubstituted-1,2,3-triazoles. These compounds 3a–3p were synthesized in good yield by refluxing α-aminoacetophenones and hydrazines in glacial acetic acid. The reaction proceeds under mild conditions and is compatible with various functional groups.

  摘要 我们开发了一种新型有效的制备 2,4-二取代-1,2,3-三唑的方法。这些化合物 3a-3p 通过在冰醋酸中回流 α-氨基苯乙酮和肼以良好的收率合成。该反应在温和的条件下进行，并与各种官能团相容。
• Another Way to the Synthesis of 1,2,3-Triazoles
  作者：Beihua Xu、Yongzhou Hu

  DOI：10.1002/jhet.1095

  日期：2013.7

  The reactions of α‐bromoacetophenones with methylhydrazine in refluxing acetic acid generated 2‐methyl‐4‐aryl‐2H‐[1,2,3]triazoles in good yields. The method was developed by the reactions of α‐bromoacetophenones with phenylhydrazines in the presence of cupric ion, leading to 2,4‐diary‐2H‐[1,2,3]triazoles. The structures were established on the basis of corresponding IR, 1H NMR, and elemental analysis data.