(2S)-apiforol | 55167-29-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2S)-apiforol
• 英文别名: Apiforol；(2S)-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-4,5,7-triol
• CAS: 55167-29-8
• 化学式: C₁₅H₁₄O₅
• 分子量: 274.273
• InChiKey: RPKUCYSGAXIESU-ABLWVSNPSA-N

物化性质

• 沸点：
  569.2±50.0 °C(Predicted)
• 密度：
  1.492±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S)-apiforol 在 盐酸 作用下， 反应 0.25h， 生成 4′,5,7-trihydroxyflavylium chloride
  参考文献：
  名称：

  山茱萸花提取物生物合成3-脱氧花青素

  摘要：

  摘要 来自 Sinningia cardinalis 花的可溶性酶制剂催化 NADPH 依赖性还原 (2 S )-柚皮素为相应的 flavan-4-ol apiforol (leucoapigeninidin) 和 (2 S )-圣草酚为木犀草素 (leucoluteolinidin)。NADPH 可以在很大程度上被 NADH 取代。该反应的最佳 pH 值约为 6.0，并且被对氯汞苯甲酸盐抑制约 50%。讨论了 3-脱氧花青素途径反应的重要性以及黄烷酮 4-还原酶和二氢黄酮醇 4-还原酶的关系，它们在花提取物中也被发现具有活性。

  DOI：

  10.1016/0031-9422(88)84093-7
• 作为产物：
  描述：

  (S)-柚皮素 在 borohydride 作用下， 生成 (2S)-apiforol
  参考文献：
  名称：

  山茱萸花提取物生物合成3-脱氧花青素

  摘要：

  摘要 来自 Sinningia cardinalis 花的可溶性酶制剂催化 NADPH 依赖性还原 (2 S )-柚皮素为相应的 flavan-4-ol apiforol (leucoapigeninidin) 和 (2 S )-圣草酚为木犀草素 (leucoluteolinidin)。NADPH 可以在很大程度上被 NADH 取代。该反应的最佳 pH 值约为 6.0，并且被对氯汞苯甲酸盐抑制约 50%。讨论了 3-脱氧花青素途径反应的重要性以及黄烷酮 4-还原酶和二氢黄酮醇 4-还原酶的关系，它们在花提取物中也被发现具有活性。

  DOI：

  10.1016/0031-9422(88)84093-7

文献信息

• Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
  申请人：Nappa Olivera Alvaro

  公开号：US20070232495A1

  公开（公告）日：2007-10-04

  The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
• Medical devices and methods for local delivery of elastin-stabilizing compounds
  申请人：Biggs Paul David

  公开号：US20070282422A1

  公开（公告）日：2007-12-06

  This invention relates to medical devices and an elastin-stabilizing compound, such as a phenolic tannin, the medical device being adapted to release the elastin-stabilizing compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
• [EN] DELIVERY OF COMPOUNDS<br/>[FR] ADMINISTRATION DE COMPOSÉS
  申请人：COOK INC

  公开号：WO2007133479A2

  公开（公告）日：2007-11-22

  [EN] Medical devices (10) include an elastin-stabilizing compound, such as a phenolic tannin. The medical device (10) is adapted to release the elastin-stabilizing compound within a body of a patient. Treatment of disease, such as aneurysms and aortic dissection is described. Medical devices may include coated stents (10), grafts, stent grafts, balloons and catheters (410).
  [FR] La présente invention concerne des dispositifs médicaux (10) comportant un composé stabilisateur de l'élastine, tel qu'un tanin phénolique. Le dispositif médical (10) est adapté pour libérer le composé stabilisateur de l'élastine dans un organisme d'un patient. L'invention concerne également le traitement de maladie, telle que des anévrismes et la dissection aortique. Les dispositifs médicaux peuvent comprendre des endoprothèses revêtues (10), des greffons, des greffons d'endoprothèse, des ballonnets et des cathéters (410).
• Biosynthesis of 3-deoxyanthocyanins with flower extracts from Sinningia cardinalis
  作者：K. Stich、G. Forkmann

  DOI：10.1016/0031-9422(88)84093-7

  日期：1988.1

  Abstract Soluble enzyme preparations from flowers of Sinningia cardinalis catalyse a NADPH-dependent reduction of (2 S )-naringenin to the respective flavan-4-ol apiforol (leucoapigeninidin) and of (2 S )-eriodictyol to luteoforol (leucoluteolinidin). NADPH can be substituted to a great extent by NADH. The reaction has a pH optimum around 6.0 and is inhibited about 50% by p -chloromercuribenzoate.

  摘要 来自 Sinningia cardinalis 花的可溶性酶制剂催化 NADPH 依赖性还原 (2 S )-柚皮素为相应的 flavan-4-ol apiforol (leucoapigeninidin) 和 (2 S )-圣草酚为木犀草素 (leucoluteolinidin)。NADPH 可以在很大程度上被 NADH 取代。该反应的最佳 pH 值约为 6.0，并且被对氯汞苯甲酸盐抑制约 50%。讨论了 3-脱氧花青素途径反应的重要性以及黄烷酮 4-还原酶和二氢黄酮醇 4-还原酶的关系，它们在花提取物中也被发现具有活性。