多潘 | 520-09-2

• 物质功能分类: 原料药 - 抗肿瘤药 - 烷化剂类抗肿瘤药
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 多潘
• 中文别名: 甲尿嘧啶氮芥；2,6-二羟基-4-甲基-5-[双(2-氯乙基)氨基]嘧啶；甲基尿嘧啶氮芥
• 英文名称: 5-[bis-(2-chloro-ethyl)-amino]-6-methyl-1H-pyrimidine-2,4-dione
• 英文别名: 5-[Bis-(2-chlor-aethyl)-amino]-6-methyl-1H-pyrimidin-2,4-dion；Chloraethylaminouracil；Dopane；Dopan；5-[bis(2-chloroethyl)amino]-6-methyl-1H-pyrimidine-2,4-dione
• CAS: 520-09-2
• 化学式: C₉H₁₃Cl₂N₃O₂
• 分子量: 266.127
• InChiKey: SDTHIDMOBRXVOQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.5820 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  ——	5-[bis-(2-hydroxy-ethyl)-amino]-6-methyl-1H-pyrimidine-2,4-dione	31492-83-8	C9H15N3O4	229.236
  5-氨基-2,4-二羟基-6-甲基嘧啶	5-amino-2,4-dihydroxy-6-methylpyrimidine	6270-46-8	C5H7N3O2	141.129

反应信息

• 作为产物：
  描述：

  5-氨基-2,4-二羟基-6-甲基嘧啶 在 氯化亚砜 、 溶剂黄146 作用下， 生成 多潘
  参考文献：
  名称：

  Chang; Yuean, Yaoxue Xuebao/Acta pharmaceutica Sinica, 1958, vol. 6, p. 139

  摘要：

  DOI：

文献信息

• THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS
  申请人：BROWN Dennis M.

  公开号：US20160045502A1

  公开（公告）日：2016-02-18

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to mustard-based alkylating agents such as uracil mustard and analogs, derivatives, or prodrugs thereof, including 6-methyluracil mustard and 6-ethyluracil mustard.

  本发明描述了一种改善先前受到治疗性能不佳限制的治疗剂的治疗效果的方法和组合物，通过改善单药疗法的功效或减少副作用。这种方法和组合物特别适用于芥子碱基烷基化剂，例如尿嘧啶芥和其类似物、衍生物或前药，包括6-甲基尿嘧啶芥和6-乙基尿嘧啶芥。
• Anti-cancer device
  申请人：UNITIKA LTD.

  公开号：EP0086627A1

  公开（公告）日：1983-08-24

  An anti-cancer device having an anti-cancer drug and a blood coagulation factor fixed to a structure. This anti-cancer device is used in transcatheter arterial embolization and needle therapy with advantage and slowly releases the anti-cancer drug over an extended period by staying in the cancer tissue and its nearby area.

  一种抗癌装置，其结构中固定有抗癌药物和凝血因子。这种抗癌装置可用于经导管动脉栓塞和针刺疗法，其优势在于可在癌症组织及其附近区域长期缓慢释放抗癌药物。
• Carriers for immobilization of phsysiologically active substances
  申请人：UNITIKA LTD.

  公开号：EP0131369A2

  公开（公告）日：1985-01-16

  carrierfor immobilization of physiologically active substances is prepared by treating an assembly of regenerated cellulose fibers having a single fiber fineness of from 0.5 30 deniers and a length of at least 1 millimeter with a solution ot a polymer having an acid anhydride group. This carrier is easy to handle and permits immobilization of a large amount of a physiologically active substance. Thus it can be used as a catalyst for chemical reactions, a specific absorbent for separation and purification, a material for clinical examination, or a medical material.

  一种用于固定生理活性物质的载体是用具有酸酐基团的聚合物溶液处理再生纤维素纤维组合而成的，再生纤维素纤维的单纤维细度为 0.5-30 旦，长度至少为 1 毫米。这种载体易于处理，可以固定大量的生理活性物质。因此，它可以用作化学反应的催化剂、分离和提纯的特殊吸收剂、临床检查材料或医用材料。
• Intravascular embolizing agent containing angiogenesis inhibiting substance
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0470569A1

  公开（公告）日：1992-02-12

  The present invention relates to an intravascular embolizing agent containing an angiogenesis-inhibiting substance and an intravascular embolizing substance. The agent strengthens the antitumor effect of an angiogenesis-inhibiting substance and serves to reduce the dose and undesirable side effects. And use of the agent in concert with an anti-neoplastic agent brings about further strong and long-lasting antitumor effects.

  本发明涉及一种含有血管生成抑制物质和血管内栓塞物质的血管内栓塞剂。该制剂能加强血管生成抑制物质的抗肿瘤作用，并能减少剂量和不良副作用。该制剂与抗肿瘤制剂配合使用，可产生更强、更持久的抗肿瘤效果。
• SALTS OF 5,5'-ARYLIDENEBISBARBITURIC AND 5,5'-ARYLIDENEBIS(2-THIOBARBITURIC) ACIDS AND 5,5'-ARYLIDENEBIS(2-THIOBARBITURIC) ACIDS HAVING AN ANTIBACTERIAL, ANTI-CHLAMYDIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY
  申请人：Tets, Viktor Veniaminovich

  公开号：EP1043318A1

  公开（公告）日：2000-10-11

  The present invention relates to the production of new chemical substances having an anti-microbial, antiviral, immuno-modulating and anti-tumoral activity. This invention more precisely relates to the synthesis of new substances consisting of 5,5'-arylidenebis(2-thiobarbituric) acids and in salts of 5,5'-arylidenebisbarbituric and 5,5'-arylidenebis(2-thiobarbituric) acids of general formula (I) where X is oxygen or sulphur. R1 is hydrogen, a nitro group or an alkoxy group, R2 is hydrogen, a nitro group, an alkoxy group or halogen and Cat+ is a proton or a pyridin- or 2-hydroxyethylammonium-cation. In the preferred embodiments of these substances, the following conditions are observed: This invention also relates to eight synthesis instances of these substances, to three tables representing the chemical and physical characteristics of the substances thus obtained and to the results of five series of experiments. These synthesis instances, tables and results demonstrate the biological properties of these substances on myco-bacteria, on herpes viruses and on Chlamydia trachomatis as well as their interferon-inducing activity and the absence of acute toxicity.

  本发明涉及生产具有抗微生物、抗病毒、免疫调节和抗肿瘤活性的新化学物质。更确切地说，本发明涉及由 5,5'-亚芳基双(2-硫代巴比妥酸)和通式(I)的 5,5'-亚芳基双巴比妥酸和 5,5'-亚芳基双(2-硫代巴比妥酸)的盐组成的新物质的合成 其中 X 是氧或硫。R1 是氢、硝基或烷氧基，R2 是氢、硝基、烷氧基或卤素，Cat+ 是质子或吡啶或 2-羟乙基铵阳离子。在这些物质的优选实施方案中，应遵守以下条件： 本发明还涉及这些物质的八个合成实例、代表由此获得的物质的化学和物理特性的三个表格以及五个系列实验的结果。这些合成实例、表格和结果表明了这些物质对霉菌、疱疹病毒和沙眼衣原体的生物特性，以及它们的干扰素诱导活性和无急性毒性。