2,2-dimethyl-1-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1-propanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,2-dimethyl-1-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1-propanol
• 英文别名: 2,2-Dimethyl-1-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)propan-1-ol
• 化学式: C₁₆H₁₈N₄O
• 分子量: 282.345
• InChiKey: VSODQKUZXPUEJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯-1-苯基-1H-吡唑并[3,4-d]嘧啶 在 苯基锂 作用下， 以 四氢呋喃 为溶剂， 生成 2,2-dimethyl-1-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1-propanol
  参考文献：
  名称：

  Lithiation of 1H-pyrazolo[3,4-d]pyrimidine derivative using lithium alkanetellurolate

  摘要：

  4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was converted into alkyl 1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4-yl telluride, which was lithiated using alkyllithium followed by the reaction with electrophiles. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00132-x

文献信息

• Preparation of Nitrogen-Containing π-Deficient Heteroaromatic Grignard Reagents:  Oxidative Magnesiation of Nitrogen-Containing π-Deficient Halogenoheteroaromatics Using Active Magnesium
  作者：Osamu Sugimoto、Shigeru Yamada、Ken-ichi Tanji

  DOI：10.1021/jo026492a

  日期：2003.3.1

  The oxidative magnesiation of nitrogen-containing pi-deficient halogenoheteroaromatics using active magnesium was accomplished. Both magnesiation followed by addition of a carbonyl compound (Grignard reaction) and magnesiation in the presence of a carbonyl compound (Barbier reaction) were carried out to afford the corresponding product. Especially, the latter method enabled fused halogenodiazines such

  使用活性镁完成了含氮pi不足的卤代杂环芳烃的氧化放大作用。进行镁的放大，然后添加羰基化合物（格氏反应），以及在羰基的化合物存在下进行镁的放大（Barbier反应），得到相应的产物。特别地，后一种方法使稠合的卤素二嗪例如4-氯-1-苯基-1H-吡唑并[3，4-d]嘧啶或2-氯喹喔啉在温和的温度（-20至30℃）下氧化镁。
• Lithiation of 1H-pyrazolo[3,4-d]pyrimidine derivative using lithium alkanetellurolate
  作者：Osamu Sugimoto、Muneyoshi Sudo、Ken-ichi Tanji

  DOI：10.1016/s0040-4039(99)00132-x

  日期：1999.3

  4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was converted into alkyl 1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4-yl telluride, which was lithiated using alkyllithium followed by the reaction with electrophiles. (C) 1999 Elsevier Science Ltd. All rights reserved.
• The tellurium–lithium exchange reaction: selective functionalization of electron-deficient heteroaromatics
  作者：Osamu Sugimoto、Muneyoshi Sudo、Ken-ichi Tanji

  DOI：10.1016/s0040-4020(01)00089-8

  日期：2001.3

  Electron-deficient heteroaromatic tellurides, which was obtained from the corresponding haloheteroaromatics, reacted selectively with n-butyllithium to give the lithio derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.