2,2-dimethyl-5-nitro-1,3-dioxane lithium salt

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-dimethyl-5-nitro-1,3-dioxane lithium salt
• 英文别名: 2,2-dimethyl-5-nitro-1,3-dioxane lithium
• 化学式: C₆H₁₀LiNO₄
• 分子量: 167.091
• InChiKey: JTOYSQOQXXTJFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(氯甲基)-4-硝基苯 、 2,2-dimethyl-5-nitro-1,3-dioxane lithium salt 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以84%的产率得到2,2-dimethyl 5-p-nitrobenzylidene 1,3-dioxane
  参考文献：
  名称：

  [EN] BISPHOSPHONAMIDATE PRODRUGS AND USES THEREOF
  [FR] PROMÉDICAMENTS BISPHOSPHONAMIDATE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2011139791A3

文献信息

• Synthesis of 2-substituted-3-nitroimidazo[1,2-<i>b</i>]pyridazines as potential biologically active agents
  作者：Thierry Terme、Joséa Maldonado、Michel P. Crozet、Patrice Vanelle、Christophe Galtier、Alain Gueiffier

  DOI：10.1002/jhet.5570390125

  日期：2002.1

  first time. It was shown to react under phase-transfer catalysis conditions with 2-nitropropane anion by an SRN1 mechanism to give excellent yield of isopropylidene derivative formed from a base-promoted nitrous acid elimination of C-alkylation product. Extension of this SRN1 reaction to various nitronate anions led to a new class of 3-nitroimidazo[1,2-b]pyridazine derivatives bearing a trisub-stituted

  首次合成了一种新型的杂环还原烷基化剂6-氯-2-氯甲基-3-硝基咪唑并[1,2- b ]哒嗪。已表明通过S RN 1机理在相转移催化条件下与2-硝基丙烷阴离子反应，可得到由碱促进的亚硝酸消除C-烷基化产物形成的异亚丙基衍生物的优异收率。该S RN 1反应扩展到各种亚硝酸根阴离子导致了新的一类3-硝基咪唑并[1,2- b ]哒嗪衍生物，该衍生物在2-位带有一个三取代的双键。
• Synthesis of 3-Alkenyl-1-azaanthraquinones via Diels-Alder and Electron Transfer Reactions
  作者：Pascal Rathelot、Vincent Rémusat、Patrice Vanelle

  DOI：10.3390/71200917

  日期：——

  A convenient route to 3-alkenyl-1-azaanthraquinones via a hetero Diels-Alder reaction between an azadiene and naphthoquinone, a free radical chlorination and an electron transfer reaction is reported.

  据报道，通过氮杂二烯和萘醌之间的杂狄尔斯-阿尔德反应、自由基氯化和电子转移反应制备3-烯基-1-氮杂蒽醌的便捷途径。
• SYNTHESIS OF 2,3-DIALKYLQUINONES BY <i>BIS</i>-S_RN1 METHODOLOGY
  作者：Thierry Terme、José Maldonado、Michel P. Crozet、Patrice Vanelle

  DOI：10.1081/scc-100108240

  日期：2001.1.1

  Three series of complex dialkylquinones were prepared by reacting bis(chloromethyl)quinones with simple and more complex nitronate anions under electron transfer reaction conditions.
• New 2-alkylidenemethyl-5-nitrothiophenes: preparation via SRN1 reactions and in vitro antiprotozoan activity
  作者：P Vanelle、S Ghezali、J Maldonado、MP Crozet、F Delmas、M Gasquet、P Timon-David

  DOI：10.1016/0223-5234(94)90124-4

  日期：1994.1

  The reaction of 2-chloromethyl-5-nitrothiophene with the 2-nitropropane anion has been reinvestigated and extended to various nitronate anions to afford good yields of new 5-nitrothiophenes bearing a trisubstituted ethylenic double bond at the 2-position. These compounds were evaluated as potential antiprotozoan agents and some derivatives were found to have the same activity as that of reference compounds.
• Preparation and in vitro antiprotozoan activity of new naphthoimidazolediones
  作者：P Vanelle、S Donini、J Maldonado、M.P. Crozet、F Delmas、M Gasquet、P Timon-David

  DOI：10.1016/s0223-5234(97)84015-9

  日期：1997.6

  The original compound bearing the coplanar quinone and imidazole systems, 2-chloromethyl-4,9-dihydro-1-methyl-1H-naphtho[2,3-d]imidazol-4,9-dione reacted with various nitronate anions to afford, in moderate to good yields, new naphthoimidazolediones bearing a trisubstituted ethylenic double bond at the 2-position. These compounds were evaluated as potential antiprotozoan agents. Some derivatives were found to have a significant activity, but the naphthoquinone was found to be a less efficient pharmacophore than the nitro group.