2-Chloro-6-(4-Piperidinyloxy)Pyrazine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Chloro-6-(4-Piperidinyloxy)Pyrazine
• 英文别名: 2-chloro-6-piperidin-4-yloxypyrazine
• 化学式: C₉H₁₂ClN₃O
• mdl: MFCD09952092
• 分子量: 213.667
• InChiKey: ILHLIZGFBFJFNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Chloro-6-(4-Piperidinyloxy)Pyrazine 、 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

  摘要：

  Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

  DOI：

  10.1016/j.bmcl.2018.05.054
• 作为产物：
  描述：

  4-羟基哌啶 、 2,6-二氯吡嗪 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 生成 2-Chloro-6-(4-Piperidinyloxy)Pyrazine
  参考文献：
  名称：

  Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

  摘要：

  Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

  DOI：

  10.1016/j.bmcl.2018.05.054

文献信息

• Novel compounds and their use
  申请人：——

  公开号：US20020147200A1

  公开（公告）日：2002-10-10

  A compound of the general formula (I): 1 wherein R 1 , R 2 , X, Y and Z are as described in the specification.

  通式（I）的化合物：其中R1、R2、X、Y和Z如规范中所述。
• Compounds and their use
  申请人：Biovitrum

  公开号：US06593330B2

  公开（公告）日：2003-07-15

  A compound of the general formula (I): wherein R1, R2, X, Y and Z are as described in the specification.

  一种通式为（I）的化合物：其中R1、R2、X、Y和Z如规范所述。
• Pyrimidine compounds and their use
  申请人：Biovitrum AB

  公开号：US07247633B2

  公开（公告）日：2007-07-24

  A compound of the general formula (I): wherein R1, R2, X, Y and Z are as described in the specification.

  一种具有一般式(I)的化合物：其中R1、R2、X、Y和Z如规范中所述。
• PIPERAZINYLPYRAZINE COMPOUNDS AS AGONIST OR ANTAGONIST OF SEROTONIN 5HT-2 RECEPTOR
  申请人：BIOVITRUM AB

  公开号：EP1335907A1

  公开（公告）日：2003-08-20
• US6593330B2
  申请人：——

  公开号：US6593330B2

  公开（公告）日：2003-07-15