(14S,27R)-22,33-二甲氧基-13-甲基-2,5,7,20-四氧杂-13,28-二氮杂八环[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]三十九碳-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-十二烯(non-preferredname) | 104386-91-6

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 中文名称: (14S,27R)-22,33-二甲氧基-13-甲基-2,5,7,20-四氧杂-13,28-二氮杂八环[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]三十九碳-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-十二烯(non-preferredname)
• 英文名称: (+)-2'-Norcepharanthine
• 英文别名: (14S,27R)-22,33-dimethoxy-13-methyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene
• CAS: 104386-91-6
• 化学式: C₃₆H₃₆N₂O₆
• 分子量: 592.7
• InChiKey: ZKIAZXMDELJIMQ-IZLXSDGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  44
• 可旋转键数：
  2
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  70.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof
  申请人：Macau University of Science and Technology

  公开号：US20160106733A1

  公开（公告）日：2016-04-21

  The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.