(2-甲氧基苯氧基)-乙酸肼 | 107967-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: (2-甲氧基苯氧基)-乙酸肼
• 中文别名: 2-(2-甲氧基苯氧基)乙烷肼；2-(2-甲氧基苯氧基)乙酰肼；乙酰肼,2-(2-甲氧基苯氧基)-
• 英文名称: ortho-anisoxyacetic acid hydrazide
• 英文别名: 2-(2-methoxyphenoxy)acetohydrazide；2-Methoxy-phenoxy-essigsaeurehydrazid；(2-methoxy-phenoxy)-acetic acid hydrazide
• CAS: 107967-88-4
• 化学式: C₉H₁₂N₂O₃
• mdl: MFCD00553729
• 分子量: 196.206
• InChiKey: WGQDMRNLIVOSOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2928000090

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 2-(2-Methoxyphenoxy)acetohydrazide
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 2-(2-Methoxyphenoxy)acetohydrazide
CAS number: 107967-88-4

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H12N2O3
Molecular weight: 196.2

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (2-甲氧基苯氧基)-乙酸肼 在 盐酸 、 sodium hydroxide 作用下， 反应 8.0h， 生成 2-(2-methoxyphenyl)oxymethyl-5-mercapto-1,2,4-triazole
  参考文献：
  名称：

  通过双曼尼希型反应有效地一锅合成含手性侧链的s-三唑并[3,4- b ]-[1,3,5]噻二嗪

  摘要：

  通过单锅双曼尼希型反应开发了一种高效简便的方法，用于合成重要的手性s-三唑衍生物：（S）-3-α-苯基乙基-2,4-二氢-5-芳基-氧甲基-1,2,4-三唑[3,4- b ] -1,3,5-噻二嗪。

  DOI：

  10.1002/jhet.5570380418
• 作为产物：
  描述：

  2-甲氧基苯氧乙酸 在 对甲苯磺酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 (2-甲氧基苯氧基)-乙酸肼
  参考文献：
  名称：

  通过双曼尼希型反应有效地一锅合成含手性侧链的s-三唑并[3,4- b ]-[1,3,5]噻二嗪

  摘要：

  通过单锅双曼尼希型反应开发了一种高效简便的方法，用于合成重要的手性s-三唑衍生物：（S）-3-α-苯基乙基-2,4-二氢-5-芳基-氧甲基-1,2,4-三唑[3,4- b ] -1,3,5-噻二嗪。

  DOI：

  10.1002/jhet.5570380418

文献信息

• 10-Camphorsulfonic acid ((±)-CSA) catalyzed facile one-pot synthesis of a new class of 2,5-disubstituted 1,3,4-oxadiazoles
  作者：Siva Nagi Reddy Mule、Sailaja Kumari Battula、Ganapathi Velupula、Dinneswara Reddy Guda、Hari Babu Bollikolla

  DOI：10.1039/c4ra11218k

  日期：——

  A convenient and efficient one-pot synthesis of 2,5-disubstituted-1,3,4-oxadizoles is described. Various carboxylic acid hydrazides reacted efficiently with different carboxylic acid chlorides and 10-camphorsulfonic acid. This methodology was successfully applied to the synthesis of a series of 2H-chromene substituted 1,3,4-oxadiazole derivatives in good to high yields.

  描述了一种方便且有效的一锅合成2,5-二取代-1,3,4-恶二唑。各种羧酸酰肼可与不同的羧酸氯化物和10-樟脑磺酸有效地反应。该方法已成功地用于合成一系列2 H-色烯取代的1,3,4-恶二唑衍生物，收率高至高。
• <i>N</i> ‐Amino‐1,8‐Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono‐N‐Substituted Hydrazines and Hydrazides
  作者：Mesram Manoj Kumar、Parikibanda Venkataramana、Parikibanda Yadagiri Swamy、Yadaiah Chityala

  DOI：10.1002/chem.202102593

  日期：2021.12.15

  N-Amino-1,8-naphthalimide was used as a protecting group and a reagent to selective synthesis of various mono-N-substituted hydrazines and hydrazides. In all these reactions, the protecting reagent N-amino-1,8-naphthalimide was easily regenerated in good yields by the hydrazinolysis. All these transformations showed good functional-group tolerance and can be used for large scale C−N cross-coupling

  N-氨基-1,8-萘二甲酰亚胺用作保护基团和试剂，用于选择性合成各种单-N-取代的肼和酰肼。在所有这些反应中，保护试剂N-氨基-1,8-萘二甲酰亚胺很容易通过肼解以良好的产率再生。所有这些转化都显示出良好的官能团耐受性，可用于大规模的 CN 交叉偶联反应。
• Zur Kenntnis der 2-Amino-1,3,4-oxdiazole Mitt.: 2-Amino-5-aryloxy(thio)alkyl-1,3,4-oxdiazole
  作者：H. Gehlen、K.-H. Uteg

  DOI：10.1002/ardp.19683011205

  日期：——

  Die Einwirkung von Bromcyan auf Aryloxy(thio)alkansäurehydrazide (I) führt zu den 2‐Amino‐5‐aryloxy(thio)alkyl‐1,3,4‐oxdiazolen (II). Einige Reaktionen von II, wie die Addition von Phenylisocyanant, die Alkoholyse und die Ringöffnung mit Acylhydrazinen werden beschrieben. Charakteristische IR‐Absorptionsbanden werden angegeben.

  溴化氰对芳氧基（硫代）链烷酸酰肼（I）的作用导致 2-氨基-5-芳氧基（硫代）烷基-1,3,4-恶二唑（II）。描述了II的一些反应，例如异氰酸苯酯的加成、醇解和与酰基肼的开环。给出了特征红外吸收带。
• Soluble poly(ethylene glycol) supported efficient synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
  作者：Zheng Li、Jingya Yang、Junke Wang、Xicun Wang

  DOI：10.1002/hc.20253

  日期：——

  An efficient soluble poly(ethylene glycol) (PEG) supported liquid-phase parallel synthetic method for 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles is described. 2-Aryl-5-(4′-methoxycarbonylphenoxymethyl)-1,3,4-oxadiazoles and 2-aryloxymethyl-5-(4′-methoxycarbonylphenoxyacetamido)-1,3,4-thiadiazoles are synthesized in high yield and high purity using this polymer supported strategy. © 2006

  描述了一种用于 2,5-二取代 1,3,4-恶二唑和 1,3,4-噻二唑的高效可溶性聚 (乙二醇) (PEG) 支持的液相平行合成方法。使用 2-Aryl-5-(4'-methoxycarbonylphenoxymethyl)-1,3,4-oxadiazoles 和 2-aryloxymethyl-5-(4'-methoxycarbonylphenoxyacetamido)-1,3,4-thiadiazoles 以高收率和高纯度合成这种聚合物支持的策略。© 2006 Wiley Periodicals, Inc. 杂原子化学 17:664–669, 2006; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20253
• Husain, M. I.; Amir, Mohd; Singh, Eira, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 251 - 254
  作者：Husain, M. I.、Amir, Mohd、Singh, Eira

  DOI：——

  日期：——