(20S)-3beta,20-二(二甲基氨基)孕甾-5-烯 | 6869-45-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: (20S)-3beta,20-二(二甲基氨基)孕甾-5-烯
• 英文名称: Kurchessin
• 英文别名: Kurchessine；(3S,8S,9S,10R,13S,14S,17S)-17-[(1S)-1-(dimethylamino)ethyl]-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine
• CAS: 6869-45-0
• 化学式: C₂₅H₄₄N₂
• 分子量: 372.638
• InChiKey: YTNIUPZRMQLHNV-XSIUSZODSA-N

物化性质

• 熔点：
  140-141° (from acetone)
• 比旋光度：
  D20 -37° (c = 1.9); D22 -36° (c = 1.112 in CHCl3); D22 -17° (c = 1.050 in methanol)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 、 一水合肼 、 三乙二醇 作用下， 生成 (20S)-3beta,20-二(二甲基氨基)孕甾-5-烯
  参考文献：
  名称：

  Cerny et al., Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 378,382, 383

  摘要：

  DOI：

文献信息

• Comparison of anti amoebic activity of stereoisomeric diamino and monoamino pregnene alkaloids and their N-methylated analogs
  作者：RAJ M VAID、K K BHUTANI

  DOI：10.1007/s12039-012-0346-x

  日期：2013.1

  The steroidal alkaloid 3β, 20α-diamino-pregn-5-ene (kurchamine) obtained from the stem bark of Holarrhena antidysenterica is reported to have appreciable amoebicidal activity. Its three stereoisomers namely 3α, 20β-diamino-pregn-5-ene, 3β, 20β-diamino-pregn-5-ene and 3α,20α-diamino-pregn-5-ene and their intermediate stereoisomeric monoamino pregnene alkaloids namely 3β-amino-pregn-5-ene-20-one, 3α-amino-pregn-5-ene-20-one, 20α -amino-pregn-5-ene-3β-ol, 20β-amino-pregn-5-ene-3β-ol were synthesized. The natural stereoisomer and synthesized diamino and monoamino stereoisomers were N-methylated and all the compounds were evaluated for amoebicidal activity comparison. The natural stereoisomer 3β,20α-diamino-pregn-5-ene (kurchamine) was found to be superior than other stereoisomers and N-methylation was found to have insignificant effect on amoebicidal activity of stereoisomers.

  从印度白花木（Holarrhena antidysenterica）的树皮中获得的类固醇生物碱3β, 20α-二氨基孕-5-烯（库尔喹明）据报道具有显著的阿米巴杀灭活性。其三种立体异构体，分别为3α, 20β-二氨基孕-5-烯、3β, 20β-二氨基孕-5-烯和3α, 20α-二氨基孕-5-烯，以及它们的中间立体异构体单氨基孕烯生物碱，包括3β-氨基孕-5-烯-20-酮、3α-氨基孕-5-烯-20-酮、20α-氨基孕-5-烯-3β-醇、20β-氨基孕-5-烯-3β-醇均已合成。天然立体异构体和合成的二氨基及单氨基立体异构体均进行了N-甲基化处理，并对所有化合物的阿米巴杀灭活性进行了比较评估。结果发现，天然立体异构体3β, 20α-二氨基孕-5-烯（库尔喹明）优于其他立体异构体，而N-甲基化对立体异构体的阿米巴杀灭活性影响不显著。
• Method for preparing a cellulose sponge
  申请人：SHANXI PISHON BIOMEDICAL TECHNOLOGY CO., LTD

  公开号：US10815313B2

  公开（公告）日：2020-10-27

  A method for preparing a cellulose sponge, comprising: (A) providing a solution of hydroxypropyl cellulose having a self-crosslinkable substituent; and (B) adding an initiator and a catalyst into the solution of hydroxypropyl cellulose having the self-crosslinkable substituent for crosslinking, wherein a method for preparing the hydroxypropyl cellulose having the self-crosslinkable substituent comprises: (a) dissolving hydroxypropyl cellulose in dimethylformamide to form a hydroxypropyl cellulose solution; (b) dissolving a compound comprising the self-crosslinkable substituent in dimethylformamide and slowly adding it drop by drop into the hydroxypropyl cellulose solution; (c) adding an alcohol for reaction; and (d) reacting and drying at room temperature to form the hydroxypropyl cellulose having the self-crosslinkable substituent.

  一种制备海绵纤维素的方法，包括：(A)提供具有自交联取代基的羟丙基纤维素溶液；和(B)向具有自交联取代基的羟丙基纤维素溶液中加入引发剂和催化剂以进行交联，其中制备具有自交联取代基的羟丙基纤维素的方法包括：(a) 将羟丙基纤维素溶解在二甲基甲酰胺中，形成羟丙基纤维素溶液；(b) 将包含自交联取代基的化合物溶解在二甲基甲酰胺中，并缓慢地逐滴加入羟丙基纤维素溶液中；(c) 加入醇进行反应；(d) 在室温下反应和干燥，形成具有自交联取代基的羟丙基纤维素。
• Method for predicting effect of drug
  申请人：Shanxi Pishon Biomedical Technology Co., LTD

  公开号：US10928383B2

  公开（公告）日：2021-02-23

  A method for predicting an effect of a medication or a treatment regimen to a subject suffering from a cancer, the method comprises: (A) obtaining a tissue from the subject; (B) dissociating the tissue to obtain a multicellular cluster, wherein the multicellular cluster comprises the cancer cell; (C) culturing the multicellular cluster on a cellulose sponge; (D) exposing the cultured multicellular cluster to the medication or the treatment regimen; and (E) measuring a first survival rate of the cancer cell before exposing to the medication or the treatment regimen and a second survival rate of the cancer cell after exposing to the medication or the treatment regimen, when the second survival rate is lower than the first survival rate, the method predicts positive effect of the medication or the treatment regimen to the subject.

  一种预测药物或治疗方案对癌症患者效果的方法，该方法包括(A) 从受试者身上获取组织；(B) 分解组织以获取多细胞团，其中多细胞团包括癌细胞；(C) 在纤维素海绵上培养多细胞团；(D) 将培养的多细胞团暴露于药物或治疗方案；(E) 在接触药物或治疗方案之前测量癌细胞的第一存活率，在接触药物或治疗方案之后测量癌细胞的第二存活率，当第二存活率低于第一存活率时，该方法预测药物或治疗方案对受试者的积极作用。
• Tschesche; Wiensz, Chemische Berichte, 1958, vol. 91, p. 1504,1510
  作者：Tschesche、Wiensz

  DOI：——

  日期：——
• BHUTANI, K. K.;VAID, R. M.;ALI, M.;KAPOOR, R.;SOODAN, S. R.;KUMAR, D., PHYTOCHEMISTRY, 29,(1990) N, C. 969-972
  作者：BHUTANI, K. K.、VAID, R. M.、ALI, M.、KAPOOR, R.、SOODAN, S. R.、KUMAR, D.

  DOI：——

  日期：——