(2R,4S)-4-羟基哌啶-2-羧酸甲酯盐酸盐 | 175671-44-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2R,4S)-4-羟基哌啶-2-羧酸甲酯盐酸盐
• 英文名称: (2R,4S)-4-hydroxy-2-(methoxycarbonyl)piperidinium chloride
• 英文别名: methyl 4(S)-hydroxypiperidine-2(R)-carboxylate hydrochloride；methyl (2R,4S)-4-hydroxypiperidine-2-carboxylate hydrochloride；methyl (2R,4S)-4-hydroxypiperidine-2-carboxylate;hydrochloride
• CAS: 175671-44-0
• 化学式: C₇H₁₃NO₃*ClH
• 分子量: 195.646
• InChiKey: ZZQYALUPYHIFSA-RIHPBJNCSA-N

物化性质

• 熔点：
  168-170℃

计算性质

• 辛醇/水分配系数(LogP)：
  -0.31
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基(2R,4S)-4-羟基-2-哌啶羧酸酯 在 盐酸 作用下， 以 1,4-二氧六环 、 丙酮 为溶剂， 以90%的产率得到(2R,4S)-4-羟基哌啶-2-羧酸甲酯盐酸盐
  参考文献：
  名称：

  Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes

  摘要：

  Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [H-3]-SUC or [H-3]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.083

文献信息

• Preparation of (2<i>S</i>,4<i>R</i>)-4-Hydroxypipecolic Acid and Derivatives
  作者：James Gillard、Abraham、Paul C. Anderson、Pierre L. Beaulieu、Tibor Bogri、Yves Bousquet、Louis Grenier、Ingrid Guse、Pierre Lavallée

  DOI：10.1021/jo9519874

  日期：1996.1.1
• DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2010506A1

  公开（公告）日：2009-01-07
• US7632829B2
  申请人：——

  公开号：US7632829B2

  公开（公告）日：2009-12-15
• [EN] DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS<br/>[FR] DÉRIVÉS DU DIAZÉPAN MODULATEURS DES RÉCEPTEURS DE LA CHIMIOKINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2007122103A1

  公开（公告）日：2007-11-01

  [EN] The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R³, R⁴, R⁵, R⁶, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
  [FR] L'invention porte sur de nouveaux dérivés du diazépan de formule (I) dans laquelle: A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m et n sont tels que définis dans la description et dans les revendications, et sur leurs sels physiologiquement acceptables.
• Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes
  作者：Tünde Molnár、Júlia Visy、Ágnes Simon、István Moldvai、Eszter Temesvári-Major、Gábor Dörnyei、Erzsébet Kútiné Fekete、Julianna Kardos

  DOI：10.1016/j.bmcl.2008.08.083

  日期：2008.12

  Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [H-3]-SUC or [H-3]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype. (C) 2008 Elsevier Ltd. All rights reserved.