(4E)-6-甲基-4-庚烯-2-酮 | 104728-05-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (4E)-6-甲基-4-庚烯-2-酮
• 英文名称: (E)-6-methyl-4-hepten-2-one
• 英文别名: 6-methyl-hept-4-en-2-one；6-Methyl-hept-4-en-2-on；β-Isomethylheptenon；4-Hepten-2-one, 6-methyl-；(E)-6-methylhept-4-en-2-one
• CAS: 104728-05-4
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: UURQIFMXMISCGV-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914190090

反应信息

• 作为反应物：
  描述：

  (4E)-6-甲基-4-庚烯-2-酮 在 钯 作用下， 生成 6-甲基-2-庚酮
  参考文献：
  名称：

  Wallach, Justus Liebigs Annalen der Chemie, 1911, vol. 381, p. 85

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲基庚-3-炔-2-醇 以3%的产率得到
  参考文献：
  名称：

  MA, DAWEI;LU, XIYAN, TETRAHEDRON LETT., 30,(1989) N6, C. 2109-2112

  摘要：

  DOI：

文献信息

• Isomerization of propargylic alcohols catalyzed by an iridium complex
  作者：Dawei Ma、Xiyan Lu

  DOI：10.1016/s0040-4039(01)93725-6

  日期：1989.1

  α,β-Enones were synthesized by the isomerization of propargylic alcohols catalyzed by an iridium pentahydride complex.

  通过五氢化铱配合物催化的炔丙醇的异构化反应合成了α，β-烯酮。
• Method for preparing an unsaturated carboxylic acid
  申请人：Jacquot Roland

  公开号：US20060100459A1

  公开（公告）日：2006-05-11

  The invention concerns a method for preparing an unsaturated carboxylic acid from the corresponding aldehyde. More particularly, the invention aims at preparing an aliphatic carboxylic acid having at least an unsaturation conjugated with the carbonyl group. In particular, the invention concerns the preparation of geranic acid. The invention relates to a method for preparing an unsaturated carboxylic acid from the corresponding aldehyde. Said method is characterized in that it comprises a step which consists in oxidizing said aldehyde, in controlled basic medium and using molecular oxygen or a gas containing same, in the presence of a catalyst based on palladium and/or platinum and an activator based on bismuth, in conditions such that the oxidizing is carried out by diffusion process

  这项发明涉及一种从相应的醛制备不饱和羧酸的方法。更具体地说，该发明旨在制备至少具有与羰基共轭的不饱和的脂肪族羧酸。特别是，该发明涉及葛兰酸的制备。该发明涉及一种从相应醛制备不饱和羧酸的方法。所述方法的特征在于，它包括一步，即在受控的碱性介质中，使用分子氧或含有分子氧的气体，在钯和/或铂基催化剂和基于铋的活化剂的存在下，以扩散过程进行氧化所述醛的步骤进行。
• AMINOTHIAZOLES AND THEIR USES
  申请人：Bushell Simon

  公开号：US20140315790A1

  公开（公告）日：2014-10-23

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了对治疗、预防和/或改善疾病有用的有机化合物。
• Palladium catalyzed reductive decarboxylation of allyl α-alkenyl-β-ketoesters. A new synthesis of (E)-3-alkenones
  作者：Valentine Ragoussis、Alexandros Giannikopoulos

  DOI：10.1016/j.tetlet.2005.11.122

  日期：2006.1

  The reductive decarboxylation of α-alkenyl derivatives of allyl-β-ketoesters was achieved by use of palladium(0) catalyst generated in situ from Pd(OAc)2 and PPh3, with triethylammonium formate as the hydride source, in THF. The reaction proceeds smoothly and cleanly, with linear alkenyl derivatives of allyl-β-ketoesters, to afford (E)-3-alkenones in good to excellent yields (73–92%) and high stereoselectivity

  烯丙基-β-酮酸酯的α-烯基衍生物的还原脱羧反应是通过使用由Pd（OAc）2和PPh 3原位生成的钯（0）催化剂，以甲酸三乙铵为氢化物源，在THF中实现的。该反应可与烯丙基-β-酮酸酯的线性烯基衍生物平稳且清洁地进行，以良好至极佳的收率（73–92％）和高的立体选择性（> 98％）提供（E）-3-烯酮。
• INHIBITORS OF TYROSINE KINASES AND USES THEREOF
  申请人：JANKOWSKI Orion D.

  公开号：US20100035841A1

  公开（公告）日：2010-02-11

  Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

  本文公开了抑制特定酪氨酸激酶活性的化合物。公开了制备这些化合物的方法。还公开了包括这些化合物的药物组合物。提供了使用所述化合物单独或与其他治疗剂联合治疗酪氨酸激酶介导的疾病或病症或酪氨酸激酶依赖性疾病或病症的方法。