(6E)-6-辛烯-2,3-二酮 | 205807-77-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (6E)-6-辛烯-2,3-二酮
• 英文名称: (E)-Oct-6-ene-2,3-dione
• 英文别名: Oct-6-ene-2,3-dione
• CAS: 205807-77-8
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: LYCOFTODHCHHEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-溴-2-丁烯 、 2,3-dihydro-2,2,5,6-tetramethylpyrazine 在 盐酸 、 lithium diisopropyl amide 作用下， 生成 (6E)-6-辛烯-2,3-二酮
  参考文献：
  名称：

  A novel monoalkylation of symmetrical α-diones

  摘要：

  An efficient method has been developed for the synthesis of monoalkylated 1,2-diones by using steric approach control. The dihydropyrazine 2 prepared from 2,3-butanedione and 1,2-diamino-2-methylpropane is selectively deprotonated on the less hindered methyl group to give an anion which is alkylated with alkyl iodides and activated bromides. In situ hydrolysis of the alkylated dihydropyrazines gives monoalkylated diones 4 in good yield. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00306-2

文献信息

• A novel monoalkylation of symmetrical α-diones
  作者：Damodaragounder Gopal、Durgesh V. Nadkarni、Lawrence M. Sayre

  DOI：10.1016/s0040-4039(98)00306-2

  日期：1998.4

  An efficient method has been developed for the synthesis of monoalkylated 1,2-diones by using steric approach control. The dihydropyrazine 2 prepared from 2,3-butanedione and 1,2-diamino-2-methylpropane is selectively deprotonated on the less hindered methyl group to give an anion which is alkylated with alkyl iodides and activated bromides. In situ hydrolysis of the alkylated dihydropyrazines gives monoalkylated diones 4 in good yield. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.