(9ci)-1-(2-乙氧基乙基)-1H-苯并咪唑 | 143656-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: (9ci)-1-(2-乙氧基乙基)-1H-苯并咪唑
• 英文名称: 1-(2-ethoxyethyl)benzimidazole
• 英文别名: 1-(2-ethoxy-ethyl)-1H-benzoimidazole
• CAS: 143656-17-1
• 化学式: C₁₁H₁₄N₂O
• mdl: MFCD03299062
• 分子量: 190.245
• InChiKey: JBJUUEWWQLMAJH-UHFFFAOYSA-N

物化性质

• 沸点：
  318.5±44.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-二乙基氯乙胺 、 (9ci)-1-(2-乙氧基乙基)-1H-苯并咪唑 以 N,N-二甲基甲酰胺 为溶剂， 以73%的产率得到1-(2-ethoxyethyl)-3-(2-diethylaminoethyl)benzimidazolium chloride
  参考文献：
  名称：

  Oezdemir; Goek; Guerbuez, Polish Journal of Chemistry, 2004, vol. 78, # 11-12, p. 2141 - 2147

  摘要：

  DOI：
• 作为产物：
  描述：

  苯并咪唑 、 2-乙氧基氯乙烷 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以75%的产率得到(9ci)-1-(2-乙氧基乙基)-1H-苯并咪唑
  参考文献：
  名称：

  Kuecuekbay, Hasan; Durmaz, Riza; Gueven, Mine, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 5, p. 420 - 424

  摘要：

  DOI：

文献信息

• Benzimidazolium sulfonate ligand precursors and application in ruthenium-catalyzed aromatic amine alkylation with alcohols
  作者：Nazan Kaloglu、Ismail Özdemir、Nevin Gürbüz、Mathieu Achard、Christian Bruneau

  DOI：10.1016/j.catcom.2015.10.028

  日期：2016.1

  New benzimidazolium sulfonate salts have been prepared and fully characterized. They have been associated in situ with [RuCl2(p-cymene)]2 to generate efficient catalytic systems operating at 120 °C under neat conditions in the presence of potassium tert-butylate for selective N-alkylation of primary aromatic amines into secondary amines.

  已经制备并充分表征了新的苯并咪唑磺酸盐。它们已与[RuCl 2（p- cymene）] 2原位缔合，以产生有效的催化体系，在叔丁酸钾存在下于纯条件下在120°C的条件下运行，用于将伯芳族胺选择性N-烷基化为仲胺。 。
• Palladium-Catalyzed Heck Reaction of Aryl Bromides in Aqueous Media Using Tris(N<i>-</i>Heterocyclic Carbene) Ligands
  作者：Ismail Özdemir、Serpil Demir、Bekir Çetinkaya

  DOI：10.1055/s-2007-973860

  日期：2007.4

  highly effective, easy to handle and environmentally benign process for palladium-mediated Heck reaction was developed. The in situ prepared three-component system composed of palladium(II) acetate, a tris(azolinium) bromide and potassium TERT-butoxide, quantitatively catalyzes the Heck reaction of aryl bromides in aqueous media.

  开发了一种高效、易于处理且环境友好的钯介导的 Heck 反应工艺。原位制备的三组分体系由乙酸钯（II）、三（唑啉）溴化物和叔丁醇钾组成，在水性介质中定量催化芳基溴化物的 Heck 反应。
• Synthesis and antimicrobial activity of novel gold(I) N-heterocyclic carbene complexes
  作者：Öznur Doğan、Nazan Kaloğlu、Serpil Demir、İlknur Özdemir、Selami Günal、İsmail Özdemir

  DOI：10.1007/s00706-012-0812-7

  日期：2013.3

  gold–NHC complexes (NHC = N,N’-dialkylbenzimidazol-2-ylidene) were prepared and characterized. Novel [Au(NHC)2]AuCl2-type complexes were prepared in good yields from silver–NHC complexes by treatment with [AuCl(PPh3)], following the commonly used silver carbene transfer route. All compounds were characterized using 1H and 13C NMR spectroscopy, elemental analysis, and IR. The gold complexes showed antimicrobial

  摘要制备并表征了苯并咪唑鎓盐和六个阴离子金-NHC络合物（NHC = N，N'-二烷基苯并咪唑 -2-亚基）。按照常用的银卡宾转移路线，用[AuCl（PPh 3）]处理，可以从银-NHC络合物中以高收率制备新型[Au（NHC）2 ] AuCl 2型络合物。使用1 H和13 C NMR光谱，元素分析和IR表征所有化合物。金复合物显示出对革兰氏阳性/阴性和真菌菌株的抗菌活性。 图形概要
• Nitrogen-containing organic compound, resist composition and patterning process
  申请人：Watanabe Takeru

  公开号：US20050095533A1

  公开（公告）日：2005-05-05

  Resist compositions comprising nitrogen-containing organic compounds having a benzimidazole structure and a specific ether chain moiety have an excellent resolution, form precisely configured patterns with minimized roughness of sidewalls and are useful in microfabrication using electron beams or deep-UV light.

  含有苯并咪唑结构和特定醚链基团的含氮有机化合物组成的抗蚀组合物具有优异的分辨率，可以形成精确配置的图案，且侧壁粗糙度最小，适用于使用电子束或深紫外光进行微型加工。
• PROCESS FOR PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
  申请人：YUHAN CORPORATION

  公开号：US20130116439A1

  公开（公告）日：2013-05-09

  The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefore. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.

  本发明涉及一种制备2-甲基-2'-苯基丙酸衍生物的过程，该衍生物具有抗组胺活性，中间体化合物及其制备过程。根据本发明，可以在工业规模上高产高纯地制备有药用价值的2-甲基-2'-苯基丙酸衍生物。