4-[[5-[[4-(2-Methoxyquinoline-4-carbonyl)piperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[[5-[[4-(2-Methoxyquinoline-4-carbonyl)piperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile
• 化学式: C₂₇H₂₆N₆O₂
• 分子量: 466.5
• InChiKey: MKNUHJVBUZSTGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  87.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Geranylgeranyl transferase inhibitor screening assay
  申请人：——

  公开号：US20020072081A1

  公开（公告）日：2002-06-13

  The present invention is directed toward a GGTase-I competitive binding assay which can be used to determine the relative GGTase-I inhibitory potency of test compounds. The present invention is also directed toward radiolabeled geranylgeranyl-protein transferase type-I inhibitor compounds which are useful to label GGTase-I in assays, whether cell-based, tissue-based or in whole animal.

  本发明涉及一种GGTase-I竞争结合测定法，可用于确定测试化合物的相对GGTase-I抑制效力。本发明还涉及放射标记的戊二醇基蛋白转移酶-I抑制剂化合物，可用于在细胞、组织或整个动物中标记GGTase-I。
• INHIBITORS OF PRENYL-PROTEIN TRANSFERASES
  申请人：Merck & Co., Inc.

  公开号：EP1165084A1

  公开（公告）日：2002-01-02
• EP1165084A4
  申请人：——

  公开号：EP1165084A4

  公开（公告）日：2002-05-15
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASES<br/>[FR] INHIBITEURS DE PRENYL-PROTEINE TRANSFERASES
  申请人：MERCK & CO INC

  公开号：WO2000051614A1

  公开（公告）日：2000-09-08

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases. In particular, the invention relates to prenyl-protein transferase inhibitors which are efficacious in vivo as inhibitors of geranylgeranyl-protein transferase type I (GGTase-I) and that inhibit the cellular processing of both the H-Ras protein and the K4B-Ras protein. Such therapeutic compounds are useful in the treatment of cancer.