(R)-2,2-二甲基-3-甲酰基 4-噻唑烷羧酸 | 55878-44-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-2,2-二甲基-3-甲酰基 4-噻唑烷羧酸
• 中文别名: (R)-2,2-二甲基-3-甲酰基4-噻唑烷羧酸
• 英文名称: L-4-carboxy-3-formyl-2,2-dimethylthiazolidine
• 英文别名: 2,2-dimethyl-thiazolidine-4-carboxylic acid；(R)-3-formyl-2,2-dimethyl-thiazolidine-4-carboxylic acid；N-formyl-N,S-isopropylidene-L-cysteine；(R)-3-Formyl-2,2-dimethyl-thiazolidin-4-carbonsaeure；4-Carboxy-3-formyl-2,2-dimethylthiazolidin；(4R)-3-formyl-2,2-dimethyl-1,3-thiazolidine-4-carboxylic acid
• CAS: 55878-44-9
• 化学式: C₇H₁₁NO₃S
• 分子量: 189.235
• InChiKey: LPVHVQFTYXQKAP-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  82.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-2,2-二甲基-3-甲酰基 4-噻唑烷羧酸 在 1,4-二氧六环 、 sodium hydroxide 、 二氯甲烷 、 氯甲酸乙酯 、 三乙胺 作用下， 生成 (R)-n-(3-甲酰基-2,2-二甲基-噻唑烷-4-羧基)-甘氨酸
  参考文献：
  名称：

  A New Synthesis of Cysteinyl Peptides¹

  摘要：

  DOI：

  10.1021/ja01538a037
• 作为产物：
  描述：

  甲酸 、 (4R)-2,2-二甲基-4-噻唑烷甲酸 在 sodium formate 、 乙酸酐 作用下， 生成 (R)-2,2-二甲基-3-甲酰基 4-噻唑烷羧酸
  参考文献：
  名称：

  A New Synthesis of Cysteinyl Peptides¹

  摘要：

  DOI：

  10.1021/ja01538a037

文献信息

• Synthesis of the N-terminal tripeptide sequence of oxytocin with various protective groups for the cysteine residue
  作者：A. K. Ivanov、E. E. Lavut、A. A. Antonov、V. N. Karel'skii

  DOI：10.1007/bf00598080

  日期：1989.9

  protective groups at the sulfur and nitrogen atoms in the cysteine molecule on the reactivity of this amino acid in the peptide condensation reaction has been investigated. The synthesis of the N-terminal tripeptide sequence of oxytocin was selected as a model reaction. For identifying the compounds synthesized and checking their purity, in addition to traditional physicochemical methods (TLC, melting points

  已经研究了半胱氨酸分子中硫和氮原子处保护基团的性质对该氨基酸在肽缩合反应中的反应性的影响。选择合成催产素的 N 端三肽序列作为模型反应。为了鉴定合成的化合物并检查其纯度，除了传统的物理化学方法（TLC、熔点、旋光角）外，还广泛使用了 13 C NMR 方法。
• Synthesis of a Series of Hexitol and Aminodeoxyhexitol Mononitrate Derivatives Containing a Sulfur Group and Pharmacological Evaluation on Isolated Rat Aortas
  作者：Jean Pierre Nallet、Anne Lise Mégard、Christian Arnaud、Denis Bouchu、Pierre Lantéri、Marie-Luce Béa、Vincent Richard、Alain Berdeaux

  DOI：10.1002/(sici)1099-0690(199805)1998:5<933::aid-ejoc933>3.0.co;2-j

  日期：1998.5

  possible influence on tolerance phenomenon, it was important to check the vasorelaxing effects of our compounds compared to those of commercial organic nitrates of similar structures such as isosorbide mononitrate or isosorbide dinitrate. All the compounds were tested on isolated rat aortas; some of these products exhibited an interesting activity.

  作为我们研究用于治疗心绞痛的新型有机硝酸盐的一部分，我们研究了一系列含有硫基团的己糖醇和氨基脱氧己糖醇单硝酸酯衍生物。由于巯基的组织储存的消耗似乎在这种现象的发展中起重要作用，因此在硝酸盐衍生物中添加硫基团可以防止长期治疗期间硝酸盐耐受性的发展。在研究作用持续时间和对耐受现象的可能影响之前，重要的是检查我们的化合物与类似结构的商业有机硝酸盐（如单硝酸异山梨酯或硝酸异山梨酯）的血管舒张作用相比。所有化合物均在离体的大鼠主动脉上进行测试；
• King et al., Journal of the Chemical Society, 1957, p. 873,879
  作者：King et al.

  DOI：——

  日期：——
• Inhibitors of biotin biosynthesis as potential herbicides
  作者：Ayelet Nudelman、Dana Marcovici-Mizrahi、Abraham Nudelman、Dennis Flint、Vernon Wittenbach

  DOI：10.1016/j.tet.2003.12.047

  日期：2004.2

  Isosteric derivatives and analogues of the 7-keto-8-aminopelargonic acid (KAPA), 7,8-diaminopelargonic acid (DAPA) and desthiobiotin (DTB) vitamer intermediates involved in the biosynthetic pathway of biotin were prepared and evaluated as potential herbicides. The most active compound was desmethyl-KAPA which displayed a GR(50) (concentration of the active compound that causes a 50% growth inhibition) value of 8 ppm, where values <50 ppm are considered herbicidal. Other KAPA analogs where the terminal Me group was replaced by bulkier substituents such as Et, i-Pr and HOCH2 showed moderate activity. (C) 2003 Elsevier Ltd. All rights reserved.
• Decoration of Au and Ag Nanoparticles on Self-Assembling Pseudopeptide-Based Nanofiber by Using a Short Peptide as Capping Agent for Metal Nanoparticles
  作者：Partha Pratim Bose、Michael G. B. Drew、Arindam Banerjee

  DOI：10.1021/ol0708471

  日期：2007.6.1

  The surface of a nanofiber that is formed from a self-assembling pseudopeptide has been decorated by gold and silver nanoparticles that are stabilized by a dipeptide. Transmission electron microscopic images make the decoration visible. In this paper, a new strategy of mineralizing a pseudopeptide based nanofiber by gold and silver nanoparticles with use of a two-component nanografting method is described.