8-methoxyquinoline-5-sulfonic Acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methoxyquinoline-5-sulfonic Acid
• 化学式: C₁₀H₉NO₄S
• 分子量: 239.25
• InChiKey: AFPQUGBYSAOVCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds for inhibiting diseases and preparing cells for transplantation
  申请人：Clark Anne

  公开号：US20070015737A1

  公开（公告）日：2007-01-18

  Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involved administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and method of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such an diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor and cells for transplantation.

  用于治疗淀粉样变性的方法和组合物。具体来说，提供了用于抑制、预防和治疗淀粉样沉积的方法和组合物，例如在胰岛中，其中淀粉样沉积是与胰岛淀粉样多肽（IAPP）相关的淀粉样沉积或沉积物。本发明的方法涉及向受试者施用一种抑制IAPP相关淀粉样沉积的治疗化合物。因此，本发明的组合物和方法对于抑制在发生此类淀粉样沉积的疾病中的IAPP相关淀粉样变性是有用的，比如糖尿病。本发明还提供了一种用于制备适合移植到哺乳动物体内的细胞的方法，这些细胞能够形成纤维，该方法包括将细胞与纤维形成抑制剂接触。具体而言，该方法为用于治疗糖尿病的方法准备细胞。还提供了一种包含该抑制剂和用于移植的细胞的培养基。
• Compositions and methods for treating amyloidosis
  申请人：Queen's University at Kingston

  公开号：US20040198832A1

  公开（公告）日：2004-10-07

  Therapeutic compounds and methods for modulating amyloid aggregation in a subject, whatever its clinical setting, are described. Amyloid aggregation is modulated by the administration to a subject of an effective amount of a therapeutic compound of the formula 1 or a pharmaceutically acceptable salt or ester, such that modulation of amyloid aggregation occurs. R 1 and R 2 are each independently a hydrogen atom or a substituted or unsubstituted aliphatic or aryl group. Z and Q are each independently a carbonyl (C═O), thiocarbonyl (C═S), sulfonyl (SO 2 ), or sulfoxide (S═O) group. “k” and “m” are 0 or 1, provided when k is 1, R 1 is not a hydrogen atom, and when m is 1, R 2 is not a hydrogen atom. In an embodiment, at least one of k or m must equal 1. “p” and “s” are each independently positive integers selected such that the biodistribution of the therapeutic compound for an intended target site is not prevented while maintaining activity of the therapeutic compound. T is a linking group and Y is a group of the formula -A X wherein A is an anionic group at physiological pH, and X is a cationic group.

  本文描述了用于调节淀粉样蛋白聚集的治疗化合物和方法，无论其临床设置如何。通过向受试者施用公式1的治疗化合物的有效量或其药学上可接受的盐或酯，从而调节淀粉样蛋白聚集。其中，R1和R2分别独立地为氢原子或取代或未取代的脂肪族或芳香族基团。Z和Q分别独立地为羰基（C═O）、硫代羰基（C═S）、磺酰基（SO2）或亚磺酸基（S═O）基团。“k”和“m”为0或1，当k为1时，R1不是氢原子，当m为1时，R2不是氢原子。在一种实施方式中，k或m中至少有一个必须等于1。“p”和“s”分别是正整数，选取这些正整数使治疗化合物的生物分布不会阻止预期的靶位点，并保持治疗化合物的活性。T是连接基团，Y是公式-A X的基团，其中A是生理pH下的阴离子基团，X是阳离子基团。
• Methods and compounds for inhibiting amyloid deposits
  申请人：Queen's University at Kingston and Neurochem, Inc.

  公开号：US20040248876A1

  公开（公告）日：2004-12-09

  Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.

  本发明涉及用于治疗淀粉样变性的方法和组合物。具体而言，提供了用于抑制、预防和治疗淀粉样沉积的方法和组合物，例如在胰岛中的淀粉样沉积，其中淀粉样沉积物是岛内淀粉样多肽（IAPP）相关的淀粉样沉积或沉积物。本发明的方法包括向受试者施用抑制IAPP相关淀粉样沉积的治疗化合物。因此，本发明的组合物和方法对于抑制在发生这种淀粉样沉积的疾病中的IAPP相关淀粉样变性，例如糖尿病，非常有用。
• METHODS AND COMPOUNDS FOR INHIBITING AMYLOID DEPOSITS
  申请人：Szarek Walter A.

  公开号：US20080227767A1

  公开（公告）日：2008-09-18

  Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.

  本发明提供了在治疗淀粉样变性方面有用的方法和组合物。具体而言，提供了用于抑制、预防和治疗淀粉样沉积的方法和组合物，例如在胰岛中，其中淀粉样沉积是胰岛淀粉样多肽(IAPP)相关的淀粉样沉积或沉积物。本发明的方法涉及向受试者施用抑制IAPP相关淀粉样沉积的治疗化合物。因此，本发明的组合物和方法对于抑制IAPP相关淀粉样变性在发生此类淀粉样沉积的疾病，如糖尿病方面是有用的。
• Methods and compositions for treating amyloid-related diseases
  申请人：Kong Xianqi

  公开号：US20070010573A1

  公开（公告）日：2007-01-11

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  描述了用于治疗或预防与淀粉样蛋白相关的疾病的方法、化合物、制药组合物和试剂盒。