6-hydroxy-2-(4-hydroxyphenyl)-3-(4-hydroxybenzoyl)-benzo[b]thiophene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-hydroxy-2-(4-hydroxyphenyl)-3-(4-hydroxybenzoyl)-benzo[b]thiophene
• 英文别名: 2-(4-hydroxyphenyl)-3-(4-hydroxybenzoyl)-6-hydroxybenzo[b]thiophene；2-(4-hydroxyphenyl)-3-(4-hydroxybenzoyl)-6-hydroxybenzothiophene；[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-(4-hydroxyphenyl)methanone
• 化学式: C₂₁H₁₄O₄S
• 分子量: 362.406
• InChiKey: CTMKIRXPVZYQJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-hydroxy-2-(4-hydroxyphenyl)-3-(4-hydroxybenzoyl)-benzo[b]thiophene 、 乙酸酐 以85 %的产率得到2-(4-acetoxyphenyl)-3-(4-acetoxybenzoyl)-6-acetoxybenzo[b]thiophene
  参考文献：
  名称：

  CN116332901

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(4-hydroxyphenyl)-3-(4-methoxybenzoyl)-6-hydroxybenzo[b]thiophene 在 吡啶盐酸盐 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 以2.5 g (86.2%)的产率得到6-hydroxy-2-(4-hydroxyphenyl)-3-(4-hydroxybenzoyl)-benzo[b]thiophene
  参考文献：
  名称：

  Regioselective alkylation process for preparing substituted

  摘要：

  本发明提供了苯并噻吩的区域选择性烷基化过程。

  公开号：

  US06025495A1

文献信息

• Demethylation process for preparing benzo[b]thiophenes
  申请人：ELI LILLY AND COMPANY

  公开号：EP0875511A1

  公开（公告）日：1998-11-04

  The preparation of benzo[b]thiophenes by the acylation of alkoxy protected starting materials followed by demethylation using essentially odorless thiol compound (2-methyl-5-t-butyl benzenethiol) are provided herewith. Demethylation may be carried out in the same reaction vessel without isolation of the acylated, protected material.

  本文提供了通过醇醚保护起始材料的酰化，然后使用基本无味的硫醇化合物（2-甲基-5-t-叔丁基苯硫醇）进行去甲基化制备苯并[b]噻吩的方法。去甲基化可以在同一反应容器中进行，无需分离酰化保护的材料。
• [EN] A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE BENZO(B)THIOPHÈNE
  申请人：HEXAL AG

  公开号：WO2011047877A1

  公开（公告）日：2011-04-28

  The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

  本发明一般涉及有机化学领域，特别是关于制备苯并[b]噻吩衍生物的。这些苯并[b]噻吩衍生物可用作合成药物活性剂（如瑞洛西芬或其衍生物）的中间体。
• Non-solvated crystalline 6-hydroxy-2- (4-hydroxyphenyl) -3- [4- (2-piperidinoethoxy) benzoyl] benzo [b] thiophene hydrochloride
  申请人：——

  公开号：US20020173645A1

  公开（公告）日：2002-11-21

  The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene hydrochloride, as well as processes for their preparation.

  本发明涉及用于制备2-芳基-6-羟基-3-[4-(2-氨基乙氧基)苯甲酰基]苯并[b]噻吩的化学过程。本发明还涉及6-羟基-2-(4-羟基苯基)-3-[4-(2-哌啶基乙氧基)苯甲酰基]苯并[b]噻吩盐的晶体溶剂和非溶剂晶体形式，以及它们的制备方法。
• A phosphate-free automatic dishwashing composition
  申请人：CLEANTABS A/S

  公开号：EP0504091A1

  公开（公告）日：1992-09-16

  A phosphate-free automatic dishwashing composition comprising nonionic tenside, carboxylic acid, water-soluble alkaline compound and bleach, as well as optionally one or more adjuvants or additives, where the bleach is a chlorine-free, oxygen donating bleach, and where the automatic dishwashing composition comprises carbonate, polycarboxylate, polyfunctional carboxylic acid, silicate, and nonionic tenside. The composition may advantageously be in the form of a tablet. The automatic dishwashing composition has an excellent tea stain removing ability, despite its relatively low alkalinity.

  一种不含磷酸盐的自动洗碗组合物，由非离子絮凝剂、羧酸、水溶性碱性化合物和漂白剂以及可选的一种或多种佐剂或添加剂组成，其中漂白剂是一种不含氯、捐氧的漂白剂，自动洗碗组合物由碳酸盐、聚羧酸盐、多官能团羧酸、硅酸盐和非离子絮凝剂组成。该组合物最好是片剂形式。尽管自动洗碗组合物的碱度相对较低，但它具有出色的去茶渍能力。
• A laundry detergent composition
  申请人：CLEANTABS A/S

  公开号：EP0508934A1

  公开（公告）日：1992-10-14

  A laundry detergent composition, comprising a tenside component, a builder component having a builder A including one or more ion-exchangers, a builder B including one or more ion-transferring agents, a builder C including one or more precipitation inhibitors, a builder D including one or more soil-suspending agents as well as optionally further builders and optionally one or more adjuvants and additives. The laundry detergent composition causes less incrustations and lime depositions on the heating elements of washing machines without having to increase the dosage in case of hard supply water.

  一种洗衣粉组合物，包括絮凝剂成分、添加剂成分，其中添加剂 A 包括一种或多种离子交换剂，添加剂 B 包括一种或多种离子转移剂，添加剂 C 包括一种或多种沉淀抑制剂，添加剂 D 包括一种或多种土壤悬浮剂，以及可选的其他添加剂和可选的一种或多种佐剂和添加剂。这种洗衣粉组合物可以减少洗衣机加热元件上的结垢和石灰沉积，而无需在硬水情况下增加用量。