(S)-2,2-二甲基-4-氨基甲基-1,3-二噁烷 | 191354-52-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (S)-2,2-二甲基-4-氨基甲基-1,3-二噁烷
• 英文名称: (S)-2,2-Dimethyl-4-aminomethyl-1,3-dioxane
• 英文别名: [(4S)-2,2-dimethyl-1,3-dioxan-4-yl]methanamine
• CAS: 191354-52-6
• 化学式: C₇H₁₅NO₂
• 分子量: 145.2
• InChiKey: JVACWTVDJZDLLF-LURJTMIESA-N

物化性质

• 沸点：
  196.7±15.0 °C(Predicted)
• 密度：
  0.957±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Process for the preparation of oxazolidinones and method of use thereof
  申请人：Hollingsworth I. Rawle

  公开号：US20070265451A1

  公开（公告）日：2007-11-15

  A process for preparing N-(substituted)-C-(substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C-(substituted methyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl)-oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.

  本文介绍了一种从光学活性的C-（保护的氧甲基）-噁唑烷酮制备N-（取代）-C-（取代甲基）-噁唑烷酮、C-（取代甲基）-噁唑烷酮和N-（取代）-C-（取代甲基）-噁唑烷酮的方法，其中优选手性化合物。该方法可用于在包含多种碳数或特定取代噁唑烷酮的多种试剂的两步或三步反应中产生上述取代噁唑烷酮的组合库。使用上述方法生产的许多取代噁唑烷酮已被发现具有抗微生物活性。
• PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF
  申请人：Hollingsworth Rawle I.

  公开号：US20080146458A1

  公开（公告）日：2008-06-19

  Substituted oxazolidinone of the formula: wherein R 2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.

  描述了以下化学式的氧杂环丙酮类替代物：其中R2是选择自甲基，乙基和异丙基基团的烷基。这些化合物具有抗菌作用。
• EP1578723A4
  申请人：——

  公开号：EP1578723A4

  公开（公告）日：2006-11-02
• US7390825B1
  申请人：——

  公开号：US7390825B1

  公开（公告）日：2008-06-24
• [EN] PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF<br/>[FR] PROCEDE POUR L'ELABORATION D'OXAZOLIDINONES ET PROCEDE D'UTILISATION CORRESPONDANT
  申请人：UNIV MICHIGAN STATE

  公开号：WO2003106413A2

  公开（公告）日：2003-12-24

  A process for preparing N-(substituted)-C­- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C­- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl)­ oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.