(E)-1-(3,5-ditert-butyl-2-hydroxyphenyl)-4-dimethoxyphosphoryl-4-methylpent-1-en-3-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-1-(3,5-ditert-butyl-2-hydroxyphenyl)-4-dimethoxyphosphoryl-4-methylpent-1-en-3-one
• 化学式: C₂₂H₃₅O₅P
• 分子量: 410.5
• InChiKey: JTJSIOUUCVYEBA-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY
  申请人：Ilex Oncology Research Sàrl

  公开号：EP1551418A1

  公开（公告）日：2005-07-13
• EP1551418A4
  申请人：——

  公开号：EP1551418A4

  公开（公告）日：2006-05-03
• [EN] SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION<br/>[FR] INHIBITEURS DE KETOPHOSPHONATE SUBSTITUE CONTRE LA PROLIFERATION D'UNE CELLULE TUMORALE
  申请人：ILEX ONCOLOGY RES SARL

  公开号：WO2004026242A2

  公开（公告）日：2004-04-01

  The present invention provides for methods of treatment of cancer and the inhibition of the proliferation of tumor cells by substituted phosphonate compounds.
• [EN] THERAPEUTIC USES OF LINEAR KETOPHOSPHONATES<br/>[FR] UTILISATIONS THERAPEUTIQUES DE CETOPHOSPHONATES LINEAIRES
  申请人：ILEX ONCOLOGY RES SARL

  公开号：WO2004026243A2

  公开（公告）日：2004-04-01

  The present invention relates to the use of linear ketophosphonate compounds to decrease cholesterol and lipids in patients, including those that have been shown not to respond to statins, using the linear ketophosphonates alone or in combination with a statin and also use of linear ketophosphonates to decrease the production of β-amyloid protein.
• [EN] SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY<br/>[FR] COMPOSES DE CETOPHOSPHONATES SUBSTITUES AYANT UNE ACTIVITE ANABOLISANTE SUR LES OS
  申请人：ILEX ONCOLOGY RES SARL

  公开号：WO2004026315A1

  公开（公告）日：2004-04-01

  The present invention provides substituted ketophosphonate compositions of matter, pharmaceutical compositions and methods of use of such compositions for the treatment and/or prevention of bone diseases.