1-[2-(pyridin-4-ylmethoxy)ethyl]-1H-imidazo[4,5-c]quinolin-4-amine | 436158-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[2-(pyridin-4-ylmethoxy)ethyl]-1H-imidazo[4,5-c]quinolin-4-amine
• 英文别名: 1-[2-(Pyridin-4-ylmethoxy)ethyl]imidazo[4,5-c]quinolin-4-amine
• CAS: 436158-10-0
• 化学式: C₁₈H₁₇N₅O
• 分子量: 319.366
• InChiKey: MFHCVMFXALIADI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pharmaceutical formulation comprising an immune response modifier
  申请人：3M Innovative Properties Company

  公开号：US20030199538A1

  公开（公告）日：2003-10-23

  Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo-quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines; a fatty acid; and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.

  含有免疫应答调节剂（IRM）的制药配方，所述IRM选择自咪唑喹啉胺，咪唑四氢喹啉胺，咪唑吡啶胺，6,7-融合环烷基咪唑吡啶胺，1,2-桥联咪唑喹啉胺，噻唑喹啉胺，噁唑喹啉胺，噻唑吡啶胺，噁唑吡啶胺，咪唑萘啶胺，四氢咪唑萘啶胺和噻唑萘啶胺；脂肪酸；和与脂肪酸混溶的疏水性无极性成分，对治疗皮肤相关疾病有用。提供了新型局部制剂。在一种实施方式中，该局部制剂对于治疗光化性角化症，手术后疤痕，基底细胞癌，特应性皮炎和疣等方面具有优势。
• Heterocyclic ether substituted imidazoquinolines
  申请人：3M Innovative Properties Company

  公开号：US20040072858A1

  公开（公告）日：2004-04-15

  Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

  在1位点含有醚和杂环基或杂环芳基的咪唑喹啉和四氢咪唑喹啉化合物可作为免疫反应调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并可用于治疗包括病毒性疾病和肿瘤性疾病在内的多种疾病。
• HETEROCYCLIC ETHER SUBSTITUTED IMIDAZOQUINOLINES
  申请人：3M Innovative Properties Company

  公开号：EP1339715A2

  公开（公告）日：2003-09-03
• PHARMACEUTICAL FORMULATIONS COMPRISING AN IMMUNE RESPONSE MODIFIER
  申请人：3M Innovative Properties Company

  公开号：EP1450804A1

  公开（公告）日：2004-09-01
• US6664260B2
  申请人：——

  公开号：US6664260B2

  公开（公告）日：2003-12-16