3-[(4Ar,12aS)-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a-yl]phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[(4Ar,12aS)-2-methyl-1,3,4,5,12,12a-hexahydropyrido[3,4-b]acridin-4a-yl]phenol
• 化学式: C₂₃H₂₄N₂O
• 分子量: 344.4
• InChiKey: LEPBHAAYNPPRRA-XXBNENTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• QUATERNARY OPIOID CARBOXAMIDES
  申请人：Wentland Mark P.

  公开号：US20120302594A1

  公开（公告）日：2012-11-29

  Compounds of formulas: are disclosed. The compounds are useful for ameliorating the side effects of therapeutic opiates.

  公式为的化合物被披露。这些化合物可用于改善治疗阿片类药物的副作用。
• REMEDIES FOR NEUROPATHIC PAIN AND MODEL ANIMALS OF NEUROPATHIC PAIN
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1219624A1

  公开（公告）日：2002-07-03

  The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.

  本发明涉及一种神经病理性疼痛治疗剂，其活性成分含有通式（I）代表的化合物或其药理学上可接受的酸加成盐： (其中R1、R2、R3、R4、R5、R6、R7、R8、A和B的定义与说明书中所述的定义相同)，以及一种通过给药(+)-4a-(3-羟基苯基)-2-甲基-1,2,3,4,4a,5,12,12a-八氢-反式-喹啉并[2,3-g]异喹啉产生的动物模型。本发明使神经病理性疼痛的药物治疗成为可能。还可以评估化合物对神经病理性疼痛的治疗效果。
• 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents
  申请人：RENSSELAER POLYTECHNIC INSTITUTE

  公开号：EP2266959A1

  公开（公告）日：2010-12-29

  8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. One embodiment is the subgenus of biphenylethyl compounds:

  一般结构的 8-取代-2,6-甲桥-3-苯并氮杂环丁烷 可用作镇痛剂、止泻剂、抗惊厥剂、抗惊厥剂和抗成瘾药物。其中一种是联苯乙化合物亚属：
• Remedies for neuropathic pain and model animals of neuropathic pain
  申请人：Nagase Hiroshi

  公开号：US20060094741A1

  公开（公告）日：2006-05-04

  The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.

  本发明涉及一种治疗神经病理性疼痛的药物，其活性成分含有通式(I)代表的化合物或其药理学上可接受的酸加成盐： (其中 R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A和B的定义与说明书中描述的相同），以及通过施用(+)-4a-(3-羟基苯基)-2-甲基-1,2,3,4,4a,5,12,12a-八氢-反式-喹啉并[2,3-g]异喹啉产生的动物模型。本发明使神经病理性疼痛的药物治疗成为可能。还可以评估化合物对神经病理性疼痛的治疗效果。
• 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
  申请人：RENSSELAER POLYTECHNIC INSTITUTE

  公开号：EP1944292B9

  公开（公告）日：2016-07-06