异柳杉双黄酮 | 20931-58-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 异柳杉双黄酮
• 英文名称: isocryptomerin
• 英文别名: 6-[4-(5,7-Dihydroxy-4-oxochromen-2-yl)phenoxy]-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
• CAS: 20931-58-2
• 化学式: C₃₁H₂₀O₁₀
• 分子量: 552.494
• InChiKey: PTKBMDRXKOIHCA-UHFFFAOYSA-N

物化性质

• 沸点：
  821.4±65.0 °C(Predicted)
• 密度：
  1.545±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  异柳杉双黄酮 、 乙酸酐 以 吡啶 为溶剂， 以50 mg的产率得到isocryptomerin tetraacetate
  参考文献：
  名称：

  Ansari, F. R.; Ansari, W. H.; Rahman, W., Journal of the Indian Chemical Society, 1985, vol. 62, # 5, p. 406 - 408

  摘要：

  DOI：

文献信息

• Cytotoxic biflavonoids from Selaginella willdenowii
  作者：Gloria L. Silva、Heebyung Chai、Mahabir P. Gupta、Norman R. Farnsworth、Geoffrey A. Cordell、John M. Pezzuto、Christopher W.W. Beecher、A. Douglas Kinghorn

  DOI：10.1016/0031-9422(95)00212-p

  日期：1995.9

  Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7''-di-O-methylamentoflavone, isocryptomerin and 7''-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2'',3''-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.
• RECA INHIBITORS WITH ANTIBIOTIC ACTIVITY, COMPOSITIONS AND METHODS OF USE
  申请人：Cottarel Guillaume

  公开号：US20100029597A1

  公开（公告）日：2010-02-04

  The present invention is directed to the use of RecA inhibitors as antibiotic agents, and provides RecA inhibitors useful in treating infections. Also provided are various compositions and methods associated with RecA inhibition.
• US9155792B2
  申请人：——

  公开号：US9155792B2

  公开（公告）日：2015-10-13
• Ansari, F. R.; Ansari, W. H.; Rahman, W., Journal of the Indian Chemical Society, 1985, vol. 62, # 5, p. 406 - 408
  作者：Ansari, F. R.、Ansari, W. H.、Rahman, W.

  DOI：——

  日期：——