7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(3-methoxy-2-methylphenyl)methyl]-3-oxa-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(3-methoxy-2-methylphenyl)methyl]-3-oxa-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide
• 化学式: C₃₅H₃₇ClF₂N₂O₄
• 分子量: 623.1
• InChiKey: XGUNBNDCDWFBAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 9-Azabicyclo'3.3.1 inon-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
  申请人：Bezencon Olivier

  公开号：US20060258648A1

  公开（公告）日：2006-11-16

  The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

  本发明涉及新型9-氮杂双环[3.3.1]壬烯衍生物及相关化合物，以及它们作为药物组分在制备药物组合物中的应用。本发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，特别是它们作为肾素抑制剂的应用。
• EP1622685A1
  申请人：——

  公开号：EP1622685A1

  公开（公告）日：2006-02-08
• [EN] 9-AZABICYCLO'3.3.1!NON-6-EE DERIVATIVES WITH A HETEROATOM AT THE 3-POSITION AS RENIN INHIBITORS<br/>[FR] DERIVES DE 9-AZABICYCLO'3.3.1!NON-6-EE A HETEROATOME EN POSITION 3 SERVANT D'INHIBITEURS DE LA RENINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004096366A1

  公开（公告）日：2004-11-11

  The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.