4-Anilino-6,7-dimethoxyquinoline-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Anilino-6,7-dimethoxyquinoline-3-carboxamide
• 化学式: C₁₈H₁₇N₃O₃
• 分子量: 323.3
• InChiKey: ZKODBSQDTORCBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel 4-anilinoquinoline-3-carboxamides
  申请人：——

  公开号：US20040248923A1

  公开（公告）日：2004-12-09

  The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.

  本发明涉及公式（IA）的新型化合物，它们是JAK3激酶抑制剂，以及它们的制备方法和包含它们的药物组合物。
• NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES
  申请人：AstraZeneca AB

  公开号：EP1387830A1

  公开（公告）日：2004-02-11
• Methods Of Preventing Or Reducing A Fibrotic Response Using CSF1R Inhibitors
  申请人：Massachusetts Institute of Technology

  公开号：US20190083495A1

  公开（公告）日：2019-03-21

  Described herein are methods of preventing or reducing fibrosis comprising administering CSF1R inhibitors, coating formulations comprising CSF1R inhibitors, coatings comprising CSF1R inhibitors for implantable medical devices, CSF1R inhibitor coated implantable medical devices, as well as corresponding embodiments comprising additional agents.
• US7037925B2
  申请人：——

  公开号：US7037925B2

  公开（公告）日：2006-05-02
• [EN] NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES<br/>[FR] NOUVEAUX 4-ANILINOQUINOLINE-3-CARBOXAMIDES
  申请人：ASTRAZENECA AB

  公开号：WO2002092571A1

  公开（公告）日：2002-11-21

  The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.