1-[2-(3-Pyridin-4-ylprop-2-ynoxy)ethyl]imidazo[4,5-c]quinolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[2-(3-Pyridin-4-ylprop-2-ynoxy)ethyl]imidazo[4,5-c]quinolin-4-amine
• 化学式: C₂₀H₁₇N₅O
• 分子量: 343.4
• InChiKey: PSJRWOALAMLXHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Heterocyclic ether substituted imidazoquinolines
  申请人：3M Innovative Properties Company

  公开号：US20040072858A1

  公开（公告）日：2004-04-15

  Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

  在1位点含有醚和杂环基或杂环芳基的咪唑喹啉和四氢咪唑喹啉化合物可作为免疫反应调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并可用于治疗包括病毒性疾病和肿瘤性疾病在内的多种疾病。
• HETEROCYCLIC ETHER SUBSTITUTED IMIDAZOQUINOLINES
  申请人：3M Innovative Properties Company

  公开号：EP1339715A2

  公开（公告）日：2003-09-03
• US6664260B2
  申请人：——

  公开号：US6664260B2

  公开（公告）日：2003-12-16
• [EN] HETEROCYCLIC ETHER SUBSTITUTED IMIDAZOQUINOLINES<br/>[FR] IMIDAZOQUINOLINES SUBSTITUEES ETHER HETEROCYCLIQUE
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2002046193A2

  公开（公告）日：2002-06-13

  Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.