2-[[6-(quinolin-2-ylmethoxy)-3,4-dihydro-2H-quinolin-1-yl]methyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[[6-(quinolin-2-ylmethoxy)-3,4-dihydro-2H-quinolin-1-yl]methyl]benzoic acid
• 化学式: C₂₇H₂₄N₂O₃
• 分子量: 424.5
• InChiKey: VDMKPCVOAVIUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS
  申请人：AstraZeneca AB

  公开号：EP1210343A2

  公开（公告）日：2002-06-05
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2001012187A2

  公开（公告）日：2001-02-22

  The present invention relates to the use of certain benzoic acid derivatives of formula (I), where the substituents are as defined in the specification, which act as peroxisome proliferator activated receptor (PPAR) agonists, in particular gamma receptors (PPARη), and so are useful in the treatment of states of insulin resistance, including type 2 diabetes mellitus.