4-[4,5-bis[4-[(E)-2-carboxyethenyl]phenyl]-1H-imidazol-2-yl]benzoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4-[4,5-bis[4-[(E)-2-carboxyethenyl]phenyl]-1H-imidazol-2-yl]benzoic acid
• 化学式: C₂₈H₂₀N₂O₆
• 分子量: 480.5
• InChiKey: ICWWKRYMMXHBLI-IAGONARPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer
  申请人：Farnsworth L Amanda

  公开号：US20070026398A1

  公开（公告）日：2007-02-01

  Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method of treating or preventing pancreatic cancer in a subject.