[3S,4aR,10aR]-3-(endo-3-Benzhydryloxy-8-aza-bicyclo[3.2.1]oct-8-ylmethyl)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [3S,4aR,10aR]-3-(endo-3-Benzhydryloxy-8-aza-bicyclo[3.2.1]oct-8-ylmethyl)-6-methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline
• 英文别名: (3S,4aR,10aR)-3-[(3-benzhydryloxy-8-azabicyclo[3.2.1]octan-8-yl)methyl]-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline
• 化学式: C₃₆H₄₄N₂O₂
• 分子量: 536.758
• InChiKey: XGKSDFQPVXSXIT-BDVLTZSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation
  申请人：——

  公开号：US20020002170A1

  公开（公告）日：2002-01-03

  The invention provides a compound of formula I 1 wherein R, X, Y 1 and Y 2 are as defined in the description, and a process for preparing them. The compounds of formula I are useful as pharmaceuticals.

  这项发明提供了I1式化合物，其中R、X、Y1和Y2如描述中所定义，并提供了制备它们的方法。I式化合物在制药方面有用。
• PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION
  申请人：Novartis AG

  公开号：EP1150971A1

  公开（公告）日：2001-11-07
• [EN] PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION<br/>[FR] DERIVES DE LA PIPERIDINE AND PIPERAZINE INHIBITEURS DE LA FORMATION DES FIBRILLES A beta
  申请人：NOVARTIS AG

  公开号：WO2000047571A1

  公开（公告）日：2000-08-17

  A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of β-amyloid (Aβ) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.