(4Z)-4-hydroxyimino-4-[4-[[(E)-3-phenylprop-2-enoyl]amino]phenyl]butanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (4Z)-4-hydroxyimino-4-[4-[[(E)-3-phenylprop-2-enoyl]amino]phenyl]butanoic acid
• 化学式: C₁₉H₁₈N₂O₄
• 分子量: 338.4
• InChiKey: HYIFJZHXLGQCOX-XUJSBFJBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  99
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
  申请人：Warner-Lambert Company

  公开号：US20020161050A1

  公开（公告）日：2002-10-31

  Benzene butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, corneal ulceration, treatment of bums, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

  本文描述了苯丁酸化合物及其衍生物，以及其制备方法和制备的药物组合物，可用作基质金属蛋白酶的抑制剂，特别是明胶酶A、胶原酶-3和基质金属蛋白酶-1，并用于治疗多发性硬化症、动脉粥样硬化斑块破裂、主动脉瘤、心力衰竭、左室扩张、再狭窄、牙周病、角膜溃疡、烧伤、褥疮、创伤愈合、癌症、炎症、关节炎、骨质疏松症、肾脏疾病或其他依赖于白细胞或其他活化迁移细胞组织侵袭的自身免疫或炎症性疾病，以及急性和慢性神经退行性疾病，包括中风、头部创伤、脊髓损伤、阿尔茨海默病、肌萎缩侧索硬化症、脑淀粉样血管病、艾滋病、帕金森病、亨廷顿病、朊病、重症肌无力和杜兴肌肉萎缩症的治疗。
• US6541521B1
  申请人：——

  公开号：US6541521B1

  公开（公告）日：2003-04-01
• US6624196B2
  申请人：——

  公开号：US6624196B2

  公开（公告）日：2003-09-23