2-[4-[(Z)-1,3-diphenylpent-2-en-2-yl]phenoxy]-N,N-dimethylethanamine

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 2-[4-[(Z)-1,3-diphenylpent-2-en-2-yl]phenoxy]-N,N-dimethylethanamine
• 化学式: C₂₇H₃₁NO
• 分子量: 385.5
• InChiKey: MCRGKYXEULQSGG-RQZHXJHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION<br/>[FR] COMPOSÉS À PETITE MOLÉCULE POUR LA DIFFÉRENCIATION DE CELLULES SOUCHES
  申请人：BURNHAM INST MEDICAL RESEARCH

  公开号：WO2010033643A2

  公开（公告）日：2010-03-25

  Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof. R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2' is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofuryhnethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5', R6, R6', R7, R7' are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.