7-Chloro-4-hydroxy-3-[3-(4-methoxymethoxy-benzyl)-phenyl]-1H-quinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Chloro-4-hydroxy-3-[3-(4-methoxymethoxy-benzyl)-phenyl]-1H-quinolin-2-one
• 英文别名: 7-chloro-4-hydroxy-3-[3-[[4-(methoxymethoxy)phenyl]methyl]phenyl]-1H-quinolin-2-one
• 化学式: C₂₄H₂₀ClNO₄
• 分子量: 421.9
• InChiKey: JNVNXHMNESKCEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Hydroxyquinolone derivatives
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0481676A1

  公开（公告）日：1992-04-22

  A class of 4-hydroxy-2-(1 H)-quinolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.

  一类 4-羟基-2-(1H)-喹诺酮衍生物在 3 位被任选取代的芳基取代基取代，是 NMDA 受体的选择性非竞争性拮抗剂和/或 AMPA 受体的拮抗剂，因此可用于治疗神经退行性疾病、惊厥或精神分裂症等需要施用 NMDA 和/或 AMPA 受体拮抗剂的疾病。
• COMBINATIONS OF NMDAR MODULATING COMPOUNDS
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20170072005A1

  公开（公告）日：2017-03-16

  This disclosure features combinations of NMDAR modulating compounds. This disclosure features combinations that include one or more NMDAR antagonists and GLYX-13 (each of which is sometimes referred to herein as a ‘component”). The beneficial effects of the combination are based, in part, on the finding that administration of GLYX-13 (e.g., a single dose) can reverse and/or prevent NMDAR antagonist-induced cognitive impairment (e.g., NMDAR antagonist-induced impairment in novel object recognition; e.g., induced through repeated dosing of the NMDAR antagonist).
• US5348962A
  申请人：——

  公开号：US5348962A

  公开（公告）日：1994-09-20
• US5559125A
  申请人：——

  公开号：US5559125A

  公开（公告）日：1996-09-24