1,1'-氧基二(2-氯丙烷) | 54460-96-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1'-氧基二(2-氯丙烷)
• 英文名称: 2,2'-Dichlor-dipropylether
• 英文别名: bis-(2-chloro-propyl) ether；β.β'-Dichlor-dipropylaether；Bis-(β-chlor-propyl)-aether；Bis-(2-chlor-propyl)-aether；1,1'-oxybis(2-chloro-propane)；2-Chloro-1-(2-chloropropoxy)propane
• CAS: 54460-96-7
• 化学式: C₆H₁₂Cl₂O
• 分子量: 171.067
• InChiKey: LTJNJOSNHALAPB-UHFFFAOYSA-N

物化性质

• 沸点：
  242.21°C (rough estimate)
• 密度：
  1.1090
• 保留指数：
  1048

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909199090

反应信息

• 作为反应物：
  描述：

  1,1'-氧基二(2-氯丙烷) 生成 2,6-二甲基-1,4-二恶烷
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(3-羟基丙氧基)丙-1-醇 在 氯化亚砜 作用下， 生成 1,1'-氧基二(2-氯丙烷)
  参考文献：
  名称：

  Divinyl Ethers. Preparation and Spectra¹

  摘要：

  DOI：

  10.1021/jo01082a025

文献信息

• Substituted cyclic amine metalloprotease inhibitors
  申请人：——

  公开号：US20030105153A1

  公开（公告）日：2003-06-05

  The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I). 1 Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

  该发明提供了作为金属蛋白酶抑制剂有用的化合物，对于治疗由这些酶活性过量引起的疾病具有有效性。特别是，本发明涉及具有按照式（I）的结构的化合物。还披露了利用这些化合物或含有它们的药物组合物治疗金属蛋白酶活性引起的疾病的方法。
• Inhibitors of type 5 and type 3 17beta-hydroxysteroid dehydrogenase and methods for their use
  申请人：Endorecherche, Inc.

  公开号：US20040082556A1

  公开（公告）日：2004-04-29

  Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17&bgr;-hydroxysteroid dehydrogenase. Novel inhibitors of type 5 17&bgr;-hydroxysteroid dehydrogenase are also disclosed, as are novel inhibitors of type 3 17&bgr;-hydroxysteroid dehydrogenase.

  本发明揭示了一种针对对雄激素或雌激素活性敏感的疾病的新型医疗治疗和/或抑制疾病发展的方法。这些治疗方法利用了类型5和/或类型3的17β-羟基类固醇脱氢酶的抑制剂。本发明还揭示了新型的类型5 17β-羟基类固醇脱氢酶抑制剂，以及新型的类型3 17β-羟基类固醇脱氢酶抑制剂。
• Useful aroyl aminoacyl pyrrole compounds
  申请人：——

  公开号：US20020019436A1

  公开（公告）日：2002-02-14

  This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to, use of the compounds of the present invention as anticonvulsant agents and modulators, antiepileptic agents and modulators, neuroprotective agents and modulators, muscle relaxant agents and modulators and as agents and modulators for the treatment of neuropathic pain.

  本发明涉及具有药用价值的芳基氨基酰基吡咯类化合物，用作治疗中枢神经系统疾病的药物和调节剂，以及治疗中枢神经系统疾病的方法，其中包括但不限于使用本发明化合物作为抗癫痫剂和调节剂、抗癫痫剂和调节剂、神经保护剂和调节剂、肌肉松弛剂和调节剂以及治疗神经病性疼痛的药物和调节剂。
• Method for identifying electrophiles and nucleophiles in a sample
  申请人：Eichen Yoav

  公开号：US20090258430A1

  公开（公告）日：2009-10-15

  A method and device for identifying a molecule in a sample, the molecule comprising an electrophilic or nucleophilic moiety. The method comprises contacting the sample with a plurality of chemosensors, each of the chemosensors comprising a π-conjugated system and a moiety having a nucleophilic property or an electrophilic property; and measuring an electromagnetic property of each of the chemosensors in the sample; whereby the pattern of changes in the electromagnetic properties of the plurality of chemosensors after chemically reacting with the electrophile or nucleophile of the molecule identifies the molecule in said sample. The device comprises a substrate carrying a plurality of chemosensor molecules having at least one predetermined electromagnetic property, the at least one electromagnetic property being changeable by subjecting the chemosensor molecules to a sample containing at least one electrophile or nuclephile, wherein the pattern of change of the electromagnetic property of the plurality of chemosensor molecules allows the device to identify the electrophile or nuclephile in the sample.

  一种用于识别样品中分子的方法和装置，该分子包括亲电或亲核基团。该方法包括将样品与多个化学传感器接触，每个化学传感器包括一个π-共轭系统和一个具有亲核性或亲电性的基团；并测量样品中每个化学传感器的电磁性质；因此，在化学反应与分子的亲电或亲核基团后，多个化学传感器的电磁性质的变化模式可以识别样品中的分子。该装置包括一个基板，携带多个化学传感器分子，具有至少一个预定的电磁性质，至少一个电磁性质可通过将化学传感器分子暴露于包含至少一个亲电或亲核物质的样品中而改变，多个化学传感器分子的电磁性质的变化模式允许该装置识别样品中的亲电或亲核物质。
• METHOD FOR IDENTIFYING ELECTROPHILES AND NUCLEOPHILES IN A SAMPLE
  申请人：Eichen Yoav

  公开号：US20110281742A1

  公开（公告）日：2011-11-17

  A method and device for identifying a molecule in a sample, the molecule comprising an electrophilic or nucleophilic moiety. The method comprises contacting the sample with a plurality of chemosensors, each of the chemosensors comprising a π-conjugated system and a moiety having a nucleophilic property or an electrophilic property; and measuring an electromagnetic property of each of the chemosensors in the sample; whereby the pattern of changes in the electromagnetic properties of the plurality of chemosensors after chemically reacting with the electrophile or nucleophile of the molecule identifies the molecule in said sample. The device comprises a substrate carrying a plurality of chemosensor molecules having at least one predetermined electromagnetic property, the at least one electromagnetic property being changeable by subjecting the chemosensor molecules to a sample containing at least one electrophile or nuclephile, wherein the pattern of change of the electromagnetic property of the plurality of chemosensor molecules allows the device to identify the electrophile or nuclephile in the sample.

  一种用于鉴定样品中分子的方法和装置，其中该分子包含一个亲电或亲核基团。该方法包括将样品与多个化学传感器接触，每个化学传感器包括一个π共轭系统和一个具有亲核性或亲电性的基团；并测量样品中每个化学传感器的电磁性质；因此，在化学反应后，多个化学传感器的电磁性质变化的模式可以鉴定样品中的分子。该装置包括一个基质，携带有多个化学传感器分子，其中至少有一个预定的电磁性质，通过将化学传感器分子置于至少含有一个亲电或亲核物的样品中，可以改变至少一个电磁性质，多个化学传感器分子的电磁性质变化模式允许该装置鉴定样品中的亲电或亲核物。