1,1'-氧基二[2,3-二氯丙烷] | 7774-68-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1'-氧基二[2,3-二氯丙烷]
• 中文别名: 4-辛基儿茶酚
• 英文名称: bis(2,3-dichloro-1-propyl)ether
• 英文别名: bis-(2,3-dichloro-propyl) ether；Bis-(2,3-dichlor-propyl)-aether；1,1'-oxybis(2,3-dichloropropane)；Bis(2,3-dichloropropyl) Ether；1,2-dichloro-3-(2,3-dichloropropoxy)propane
• CAS: 7774-68-7
• 化学式: C₆H₁₀Cl₄O
• 分子量: 239.957
• InChiKey: DWUVEXODBSOVSX-UHFFFAOYSA-N

物化性质

• 沸点：
  114 °C(Press: 1 Torr)
• 密度：
  1.331±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

制备方法与用途

类别：易燃液体

爆炸物危险特性： 在空气中长期放置会生成不稳定过氧化物，受热即可能发生爆炸。

可燃性危险特性： 遇明火、受热或与氧化剂接触均可燃烧；燃烧时会排放氯化物刺激烟雾。

储运特性： 应存放在通风良好、低温干燥的库房中；轻装轻卸，并与其他氧化剂和酸类分开存放。

灭火剂： 可使用雾状水、泡沫、砂土、二氧化碳或1211灭火剂进行灭火。

反应信息

• 作为反应物：
  描述：

  1,1'-氧基二[2,3-二氯丙烷] 在 sodium hydroxide 作用下， 生成 3,3'-氧基二(2-氯-1-丙烯)
  参考文献：
  名称：

  Treatment of poly-olefinic ethers and product produced thereby

  摘要：

  公开号：

  US02339476A1
• 作为产物：
  描述：

  烯丙基醚 在 氯 作用下， 生成 1,1'-氧基二[2,3-二氯丙烷]
  参考文献：
  名称：

  Halogenation of unsaturated ethers and products produced thereby

  摘要：

  公开号：

  US02464758A1

文献信息

• [EN] PROCESS FOR HYDROGENATING DICHLOROISOPROPYL ETHER<br/>[FR] PROCÉDÉ D'HYDROGÉNATION D'ÉTHER DE DICHLOROISOPROPYLE
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2016044009A1

  公开（公告）日：2016-03-24

  Convert dichloroisopropyl ether into a halogenated derivative by contacting the dichloroisopropyl ether with a source of hydrogen and a select heterogeneous hydrogenation catalyst under process conditions selected from a combination of a temperature within a range of from 50 degrees centigrade (ºC) to 350 ºC, a pressure within a range of from atmospheric pressure (0.1 megapascals) to 1000 pounds per square inch (6.9 MPa), a liquid feed volume flow to catalyst mass ratio between 0.5 and 10 L/Kg*h and a volume hydrogen / volume liquid ratio between 100 and 5000 ml gas/ ml liquid. The halogenated derivative is at least one of 1-chloro-2-propanol and 1,2-dichloropropane 1, and glycerin monochlorohydrin.

  通过将二氯异丙醚与氢源和选择性的杂化氢化催化剂接触，在从以下过程条件的组合中选择的条件下，将二氯异丙醚转化为卤代衍生物：温度在50摄氏度（ºC）至350ºC范围内，压力在大气压（0.1兆帕）至1000磅每平方英寸（6.9兆帕）范围内，液体进料体积流量与催化剂质量之比在0.5至10 L/Kg*h之间，氢气体积/液体体积比在100至5000 ml气体/ ml液体之间。卤代衍生物至少为1-氯-2-丙醇和1,2-二氯丙烷1，以及甘油单氯水合物。
• Acyclic Nucleoside Phosphonate Derivatives and Medical Uses Thereof
  申请人：Zhong Bohua

  公开号：US20120322764A1

  公开（公告）日：2012-12-20

  The present invention relates to an acyclic nucleoside phosphonate derivative and medical uses thereof. Specifically, the present invention relates to an acyclic nucleoside phosphonate derivative of Formula I having strong potency against viruses, such as hepatitis B virus, and low cytotoxicity, or a pharmaceutically acceptable salt, isomer, hydrate or solvate thereof, wherein R 1 is H or methyl; each R 2 is independently —R 3 or —OR 3 , each R 3 is independently C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl. The present invention further relates to a process for preparing the compounds of Formula I, a pharmaceutical composition comprising the compound, and the medical uses of the compound. The acyclic nucleoside phosphonate derivative of the present invention has activity against virus such as hepatitis B virus and good in vivo behavioral traits.

  本发明涉及一种无环核苷酸膦酸酯衍生物及其医药用途。具体而言，本发明涉及一种式I的无环核苷酸膦酸酯衍生物，其对病毒（如乙型肝炎病毒）具有强效力且细胞毒性低，或其药学上可接受的盐、异构体、水合物或溶剂化物，其中R1为H或甲基；每个R2独立地是—R3或—OR3，每个R3独立地是C1-C8烷基、C3-C8环烷基。本发明还涉及制备式I化合物的方法、包含该化合物的制药组合物以及该化合物的医药用途。本发明的无环核苷酸膦酸酯衍生物具有对乙型肝炎病毒等病毒的活性和良好的体内行为特性。
• Suppression of carbonaceous deposits in a process for hydrotreating an organic feedstock containing unstable olefinic compounds
  申请人：UOP

  公开号：EP0682100A1

  公开（公告）日：1995-11-15

  An organic feedstock (1) containing thermally unstable compounds and a halogen component is hydrotreated by contacting the organic feedstock (1) and a gaseous recycle stream (7) containing hydrogen and a carbon deposit suppressing an amount of a hydrogen halide compound with a hydrogenation catalyst in a hydrogenation reaction zone (2) to stably produce a hydrogenated hydrocarbonaceous stream (3) having a reduced concentration of halogen and a halide compound stream. The resulting effluent (3) from the hydrogenation zone is separated (6) to produce the recycle stream (7) containing the hydrogen halide compound.

  将含有热不稳定化合物和卤素成分的有机原料（1）与含有氢气和碳沉积物的气态循环流（7）在氢化反应区（2）中与氢化催化剂接触，对有机原料（1）进行氢化处理，以稳定地产生卤素浓度降低的氢化碳氢化合物流（3）和卤化物流。将氢化区产生的流出物（3）分离出来（6），以产生含有卤化氢化合物的循环流（7）。
• Process for the selective removal of organic nitrates from a halogenated organic stream
  申请人：UOP

  公开号：EP0855377A1

  公开（公告）日：1998-07-29

  A feed stream containing halogenated organic compounds and trace quantities of organic nitrates is treated to produce a stream comprising halogenated organic compounds substantially free from organic nitrates by the utilization of a hydrogenation zone operated at selective hydrogenation conditions in order to convert the organic nitrates to one or more water-soluble nitrogen compounds while minimizing the production of hydrogen halide compounds. The resulting water-soluble nitrogen compounds are thereafter removed by extraction with an aqueous stream to produce the desired product stream.

  利用在选择性氢化条件下运行的氢化区处理含有卤化有机化合物和痕量有机硝酸盐的进料流，以产生基本上不含有机硝酸盐的卤化有机化合物流，从而将有机硝酸盐转化为一种或多种水溶性氮化合物，同时尽量减少卤化氢化合物的产生。随后，用水流萃取除去生成的水溶性氮化合物，以生产所需的产品流。
• EPOXY RESIN COMPOSITION EXCELLENT IN WEATHER RESISTANCE AND FIBER-REINFORCED COMPOSITE MATERIALS
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1454956A1

  公开（公告）日：2004-09-08

  The present invention relates to an epoxy resin composition comprising at least (A) an epoxy resin having a cycloalkane ring or cyclohexene ring but having neither aromatic ring nor aminic nitrogen atom, (B) a carboxylic anhydride having no aromatic ring, and (C) an ultraviolet absorbent, wherein a content of component (A) is from 70 to 100 percents by weight based on the total weight of epoxy resins, and a content of component (B) is from 70 to 100 percents by weight based on the total weight of carboxylic anhydrides. By this constitution, the present invention can provide an epoxy resin composition whose cured product excels in mechanical properties and weatherability, and a fiber reinforced composite material having excellent mechanical properties and weatherability.

  本发明涉及一种环氧树脂组合物，至少包括(A)具有环烷环或环己烯环但不具有芳香环或氨基氮原子的环氧树脂，(B)不具有芳香环的羧酸酐，以及(C)紫外线吸收剂、(C) 紫外线吸收剂，其中组分（A）的含量为环氧树脂总重量的 70%至 100%，组分 （B）的含量为羧酸酐总重量的 70%至 100%。 通过这种结构，本发明可以提供一种环氧树脂组合物，其固化产物具有优异的机械性能和耐候性，还可以提供一种具有优异机械性能和耐候性的纤维增强复合材料。