4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-6,7-dimethoxy-2-methyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-6,7-dimethoxy-2-methyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester
• 英文别名: cis-4-[(3,5-Bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-6,7-dimethoxy-2-methyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester；propan-2-yl 4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-6,7-dimethoxy-2-methyl-3,4-dihydro-2H-quinoline-1-carboxylate
• 化学式: C₂₇H₃₀F₆N₂O₆
• 分子量: 592.535
• InChiKey: JKVXTXJMOAQSGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors
  申请人：Pfizer Products Inc.

  公开号：EP0987251B1

  公开（公告）日：2004-05-19
• PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUGS AND NEUTRAL POLYMERS
  申请人：Pfizer Products Inc.

  公开号：EP1404300A1

  公开（公告）日：2004-04-07
• PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS
  申请人：Bend Research, Inc.

  公开号：EP2258352B1

  公开（公告）日：2015-05-13
• US6140342A
  申请人：——

  公开号：US6140342A

  公开（公告）日：2000-10-31
• [EN] PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUGS AND NEUTRAL POLYMERS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE DISPERSIONS DE MEDICAMENTS ET DE POLYMERES NEUTRES
  申请人：PFIZER PROD INC

  公开号：WO2003000235A1

  公开（公告）日：2003-01-03

  In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.