1,1,2,2,3,3-五氯丙烷 | 1600-37-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: 1,1,2,2,3,3-五氯丙烷
• 英文名称: 1,1,2,3,3-pentachloro-1-propene
• 英文别名: 1,1,2,3,3-Pentachlor-propen-(1)；1,1,2,3,3-Pentachlor-1-propen；1,1,2,3,3-Pentachlor-propen；3-H-Pentachlorpropen-(1)；1,1,2,3,3-pentachloropropene；1-Propene, 1,1,2,3,3-pentachloro-；1,1,2,3,3-pentachloroprop-1-ene
• CAS: 1600-37-9
• 化学式: C₃HCl₅
• 分子量: 214.306
• InChiKey: MAXQCYDCBHPIAB-UHFFFAOYSA-N

物化性质

• 熔点：
  13.5 °C
• 沸点：
  185 °C
• 密度：
  1.6317
• 保留指数：
  1041;1044

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903299090

反应信息

• 作为反应物：
  描述：

  1,1,2,2,3,3-五氯丙烷 在 硫酸 作用下， 生成 2,3,3-三氯丙-2-烯醛
  参考文献：
  名称：

  Roedig; Schoedel, Chemische Berichte, 1958, vol. 91, p. 320,326

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1,1,2,2,3,3-七氯丙烷 在 乙醚 、 氢化铝 作用下， 生成 1,1,2,2,3,3-五氯丙烷
  参考文献：
  名称：

  Roedig; Kiepert, Justus Liebigs Annalen der Chemie, 1955, vol. 593, p. 56

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PRODUCTION OF CHLORINATED PROPENES<br/>[FR] PROCÉDÉ DE PRODUCTION DE PROPÈNES CHLORÉS
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2013022677A1

  公开（公告）日：2013-02-14

  Processes for the production of chlorinated propenes are provided. The present processes make use of a feedstock comprising 1,2,3-trichloropropane and chlorinates the 1,1,2,3-tetrachloropropane generated by the process prior to a dehydrochlorination step. Production of the less desirable pentachloropropane isomer, 1,1,2,3,3-pentachloropropane, is thus minimized. The present processes provide better reaction yield as compared to conventional processes that require dehydrochlorination of 1,1,2,3-tetrachloropropane prior to chlorinating the same. The present process can also generate anhydrous HCl as a byproduct that can be removed from the process and used as a feedstock for other processes, while limiting the production of waste water, thus providing further time and cost savings.

  提供了生产氯代丙烯的工艺。目前的工艺利用包含1,2,3-三氯丙烷的原料，并在去氢氯化步骤之前氯化由该过程产生的1,1,2,3-四氯丙烷。因此，生产较不理想的五氯丙烷异构体1,1,2,3,3-五氯丙烷被最小化。与需要在氯化相同物质之前对1,1,2,3-四氯丙烷进行去氢氯化的传统工艺相比，目前的工艺提供了更好的反应产率。目前的工艺还可以生成无水HCl作为副产品，可以从工艺中去除并用作其他工艺的原料，同时限制废水的产生，从而提供进一步的时间和成本节约。
• Process For Producing Chlorinated Hydrocarbons
  申请人：Axiall Ohio, Inc.

  公开号：US20140206911A1

  公开（公告）日：2014-07-24

  The preparation of chlorinated hydrocarbons, such as pentachloropropanes, such as 1,1,1,2,3-pentachloropropane, from tetrachloropropanes, such as 1,1,1,3-tetrachloropropane, in the presence of a polyvalent antimony compound that includes a pentavalent antimony compound, such as antimony pentachloride, is described. Also described are methods for preparing optionally chlorinated alkenes, such as, tetrachloropropenes, from chlorinated alkanes, such as pentachloropropanes, in the presence of ferric chloride and a polyvalent antimony compound that includes a pentavalent antimony compound.

  氯代烃的制备，例如五氯丙烷，如1,1,1,2,3-五氯丙烷，从四氯丙烷，如1,1,1,3-四氯丙烷，在存在包括五价锑化合物的多价锑化合物的情况下进行，例如五氯化锑。还描述了在存在三氯化铁和包括五价锑化合物的多价锑化合物的情况下，从氯代烷烃，如五氯丙烷，制备可选氯代烯烃，如四氯丙烯的方法。
• PROCESS OF MAKING A CHLORINATED HYDROCARBON
  申请人：Fukuju Tadahiro

  公开号：US20120053374A1

  公开（公告）日：2012-03-01

  A process of making a chlorinated hydrocarbon through a thermal dehydrochlorination step in which an unsaturated compound represented by the following general formula (2) is obtained by thermally decomposing a saturated compound represented by the following general formula (1). CCl 3 —CCl 2-m H m —CCl 3-n H n (1) CCl 2 ═CCl 2-m H m-1 —CCl 3-n H n (2) (in the above formulas, m is 1 or 2, and n is an integer of 0 to 3.)

  通过热脱氯化步骤制备氯化碳氢化合物的过程，其中通过热分解下述一般式（1）所代表的饱和化合物获得下述一般式（2）所代表的不饱和化合物。 CCl3—CCl2-mHm—CCl3-nHn（1） CCl2═CCl2-mHm-1—CCl3-nHn（2） （在上述公式中，m为1或2，n为0至3的整数。）
• Method for Producing 1,2-Dichloro-3,3,3-Trifluoropropene
  申请人：Central Glass Company, Limited

  公开号：US20190092711A1

  公开（公告）日：2019-03-28

  A method for producing 1,2-dichloro-3,3,3-trifluoropropene according to the present invention includes the step of reacting 1,1,2,3,3-pentachloropropene with a fluorinating agent where hydrogen fluoride is used as the fluorinating agent.

  根据本发明，生产1,2-二氯-3,3,3-三氟丙烯的方法包括将1,1,2,3,3-五氯丙烯与氟化剂反应的步骤，其中氢氟酸被用作氟化剂。
• Dentin Matrix Protein 1, a Target Molecule for Cbfa1 in Bone, Is a Unique Bone Marker Gene
  作者：Jian Q. Feng、Jianghong Zhang、Sarah L. Dallas、Yongbo Lu、Shuo Chen、Xiaoyu Tan、Michael Owen、Stephen E. Harris、Mary Macdougall

  DOI：10.1359/jbmr.2002.17.10.1822

  日期：——

  Dentin matrix protein 1 (Dmp1), a phosphoprotein highly linked to dentin formation, has also been reported to be expressed in the skeleton. However, the role of Dmp1 in skeletal tissues remains unclear. To clarify the role of Dmp1 in bone formation, we characterized the expression profile of Dmp1 in bone and cartilage and examined whether Dmp1 expression was regulated by core‐binding factor a1 (Cbfa1). Studies of fetal rat calvarial (FRC) cell cultures showed that the expression of Dmp1 was associated closely with “bone nodule” formation and mineralization in vitro. In situ hybridization studies were performed to examine the spatial and temporal expression patterns of Dmp1 during development in mouse embryos from 12.5 day postcoitus (dpc) to 8 weeks postnatal; these studies showed that Dmp1 first appeared in hypertrophic cartilage cells, followed by osteoblasts, and later was expressed strongly in osteocytes. The expression profiles of Cbfa1 and Dmp1 overlapped in both cartilage and bone during development, with Cbfa1 preceding Dmp1. Examination of Dmp1 expression in Cbfa1−/− mice revealed that Dmp1 was absent in the developing bones of Cbfa1‐null mice, whereas there was essentially no change in Dmp1 expression in the arrested tooth bud. Transient transfection studies showed forced expression of Dmp1 under the control of Cbfa1 and gel shift data indicated the presence of a functional osteocalcin‐specific element (OSE)‐2 response element in the Dmp1 proximal promoter region. However, in vitro promoter studies suggested that regulation of Dmp1 by Cbfa1 was not mediated by direct binding of Cbfa1 to this site and may be through indirect mechanisms. These studies highlight Dmp1 as a unique marker gene for osteoblastic differentiation. The close association of Dmp1 and Cbfa1 in the developing skeleton suggests that Dmp1 may play an important role in bone formation.

  牙本质基质蛋白1（Dmp1）是一种与牙本质形成高度相关的磷蛋白，据报道，它也存在于骨骼中。然而，Dmp1在骨骼组织中的作用尚不清楚。为了阐明Dmp1在骨形成中的作用，我们分析了Dmp1在骨骼和软骨中的表达特征，并研究了Dmp1的表达是否受核心结合因子a1（Cbfa1）的调控。对胎鼠颅骨（FRC）细胞培养的研究表明，Dmp1的表达与“骨结节”的形成和体外矿化密切相关。为了研究小鼠胚胎从交配后12.5天（dpc）到出生后8周发育过程中的时空表达模式，我们进行了原位杂交研究；这些研究表明，Dmp1首先出现在肥厚软骨细胞中，随后出现在成骨细胞中，最后在骨细胞中强烈表达。在发育过程中，Cbfa1和Dmp1在软骨和骨骼中的表达特征重叠，Cbfa1先于Dmp1。对Cbfa1 −/−小鼠中Dmp1表达的研究表明，在Cbfa1 −/−小鼠发育中的骨骼中不存在Dmp1，而在停滞的牙芽中Dmp1的表达几乎没有变化。瞬时转染研究表明，在Cbfa1的调控下，Dmp1被强制表达，凝胶迁移数据显示，在Dmp1近端启动子区域