1,1,2,3,3,3-五氟丙基乙醚 | 380-34-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1,2,3,3,3-五氟丙基乙醚
• 中文别名: 乙基1,1,2,3,3,3-六氟丙醚
• 英文名称: 1,1,2,3,3,3-hexafluoropropyl ethyl ether
• 英文别名: 1-ethoxy-1,1,2,3,3,3-hexafluoropropane
• CAS: 380-34-7
• 化学式: C₅H₆F₆O
• mdl: MFCD00236122
• 分子量: 196.092
• InChiKey: DMECHFLLAQSVAD-UHFFFAOYSA-N

物化性质

• 沸点：
  71 °C
• 密度：
  1.321

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S16,S26,S36
• 危险类别码：
  R11
• 海关编码：
  2909199090
• 危险品运输编号：
  UN 3271
• 储存条件：
  室温和干燥环境中使用。

SDS

Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether
5.3

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS
Category 2
Flammable liquids
HEALTH HAZARDS
Category 2
Skin corrosion/irritation
Serious eye damage/eye irritation Category 2A
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Danger
Hazard statements Highly flammable liquid and vapour
Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
[Prevention]
Keep container tightly closed.
Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
measures against ignition by the static discharge and the spark.
Wash hands thoroughly after handling.
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
skin with water/shower.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.
[Storage] Store in a well-ventilated place. Keep cool.
[Disposal] Dispose of contents/container through a waste management company authorized by
the local government.
Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether
Percent: >98.0%(GC)
CAS Number: 380-34-7
Chemical Formula: C5H6F6O

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Unsuitable extinguishing Solid streams of water
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot
surfaces. -No smoking. Take measures to prevent the build up of electrostatic
charge. Use explosion-proof equipment. Wash hands and face thoroughly after
handling.
Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol
will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether

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Section 7. HANDLING AND STORAGE
Storage conditions: Keep container tightly closed. Store in a cool, dark and well-ventilated place.
Store away from incompatible materials such as oxidizing agents.
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Colour: Colorless - Very pale yellow
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
Boiling point/range: 65°C
Flash point: No data available
Flammability or explosive
limits:
No data available
Lower:
Upper: No data available
1.32
Relative density:
Solubility(ies):
[Water] No data available
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Stable under proper conditions.
Chemical stability:
Possibility of hazardous No special reactivity has been reported.
reactions:
Conditions to avoid: Spark, Open flame, Static discharge
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Hydrogen fluoride
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
No data available
Serious eye
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
Ethyl 1,1,2,3,3,3-Hexafluoropropyl Ether

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Section 12. ECOLOGICAL INFORMATION
Bioaccumulative No data available
potential(BCF):
Mobility in soil
No data available
Log Pow:
Soil adsorption (Koc): No data available
No data available
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system but exert extra care in igniting as this material is
highly flammable. Observe all federal, state and local regulations when disposing of the substance

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Section 14. TRANSPORT INFORMATION
3: Flammable liquid.
Hazards Class:
UN-No: 3271
Ethers, n.o.s.
Proper shipping name:
Packing group: II

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1,1,2,3,3,3-五氟丙基乙醚 在 硫酸 、 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成 2-氟丙二酸二乙酯
  参考文献：
  名称：

  用于生命科学合成的氟气：绿色指标，用于评估2-氟丙二酸酯合成中的选择性直接氟化

  摘要：

  使用氟气一步合成2-氟丙二酸酯的绿色度量评估与已建立的多步方法相比具有优势。

  DOI：

  10.1039/c5gc00402k
• 作为产物：
  描述：

  六氟丙烯 、 乙醇 生成 1,1,2,3,3,3-五氟丙基乙醚
  参考文献：
  名称：

  叠氮化物化学研究。第二部分 2 H-六氟丙基和2-氯-1,1,2-三氟乙基叠氮化物的光解

  摘要：

  紫外线照射2 H-六氟丙基叠氮化物产生氮和3 H-六氟-2-氮杂丁基-1-烯，其与水反应生成三氟乙醛，并经氟化物引发异构化为3 H-六氟-2-氮杂丁-2-烯。在初始产物水解后，在过量的环己烷，甲基环己烷或环己烯的存在下，叠氮化物的光解产生N-环己基-，N-（1-甲基环己基）-和N-（环己-2-烯基） -αβββ-四氟丙酰胺。这些叠氮化物分解反应可以用2 H的中间体来解释-六氟丙基氮丁烯，就像单独将2-氯-1,1,2-三氟乙基叠氮化物光解得到3-氯-1,1,3-三氟-2-氮杂丙烯并在环己烷存在下提供N-环己基氯氟乙酰胺一样。根据2-氯-1,1,2-三氟乙基亚硝基合理化。在用于将全氟丙烯转化为2 H-六氟丙基叠氮化物和全氟丙烯基叠氮化物的条件下，用叠氮化三乙基铵处理氯三氟乙烯显然仅产生2-氯-1,1,2-三氟乙基叠氮化物。

  DOI：

  10.1039/j39700001017

文献信息

• FACILE SYNTHESIS OF DIALKYL FLUOROMALONATES AND THEIR DERIVATIVES
  作者：Nobuo Ishikawa、Akio Takaoka

  DOI：10.1246/cl.1981.107

  日期：1981.1.5

  Dimethyl and diethyl fluoromalonates were prepared by the stepwise basic alcoholysis of hexafluoropropene in a total yield of 50–55%. These dialkyl fluoromalonates were alkylated with alkyl halides, and the resulting dialkyl α-fluoroalkylmalonates were cyclized with urea affording 5-fluorobarbituric acid derivatives.

  通过六氟丙烯的逐步碱性醇解制备氟丙二酸二甲酯和二乙酯，总收率为 50-55%。这些氟代丙二酸二烷基酯用卤代烷烷基化，所得α-氟代烷基丙二酸二烷基酯用尿素环化，得到5-氟巴比妥酸衍生物。
• Preparation of 2-fluoromalonic esters and related compounds from hexafluoropropene
  作者：Nobuo Ishikawa、Akio Takaoka、M.Kamal Ibrahim

  DOI：10.1016/s0022-1139(00)80949-5

  日期：1984.6

  Dimethyl and diethyl fluoromalonates were prepared from hexafluoropropene by its exhaustive alcoholysis or alternatively its ammonolysis and alcoholysis. Fluoromalonates thus obtained or their alkylated derivatives were condensed with o-phenylenediamine or its substituted derivatives to give a number of 1H-3-fluoro-1,5-dibenzodiazepin-2,4(3H,5H)-diones.

  氟丙二酸二甲酯和二乙酯是通过六氟丙烯的彻底醇解或交替进行氨解和醇解而制得的。将如此获得的氟马来酸酯或其烷基化衍生物与邻苯二胺或其取代的衍生物缩合，得到许多1 H -3-氟-1,5-二苯并二氮杂-2,4（3 H，5 H）-二酮。
• 一种去除1,1,2,3,3,3-六氟丙基氢氟醚粗品中不饱和杂质的方法
  申请人：东莞东阳光科研发有限公司

  公开号：CN113527070A

  公开（公告）日：2021-10-22

  本发明提供一种去除1,1,2,3,3,3‑六氟丙基氢氟醚粗品中不饱和杂质的方法，通过使用柱层析这一种物理方法使1,1,2,3,3,3‑六氟丙基氢氟醚和1,1,2,3,3‑五氟丙烯氢氟醚或1,2,3,3,3‑五氟丙烯氢氟醚杂质能够很好的分离，制备纯度在99％以上的1,1,2,3,3,3‑六氟丙基氢氟醚产物。本发明方法不使用危险化学，极大的提高了操作的安全性，同时不产生对环境有害的废弃物，吸附剂硅胶柱能够再生重复使用，减少了成本，节约了资源。
• Synthesis and Use of Partially Fluorinated Dialkyl Ethers Derived from Hexafluoropropylene
  作者：A. A. Il'in、Yu. L. Bakhmutov、L. M. Ivanova、G. G. Furin、T. G. Tolstikova、V. S. Sukhinin

  DOI：10.1023/b:rjac.0000024585.14553.5f

  日期：2004.1

  A procedure was developed for preparing partially fluorinated dialkyl ethers by the reaction of hexafluoropropylene with aliphatic and polyfluorinated alcohols in the presence of KOH. On treatment with concentrated sulfuric acid, these ethers form alkyl esters of acids, and on treatment with KOH, alkenyl ethers.
• Knunjanz et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1953, p. 282,288;engl.Ausg.S.255,259
  作者：Knunjanz et al.

  DOI：——

  日期：——