[4-[Tert-butyl(dimethyl)silyl]oxyphenyl]-pyridin-2-ylmethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-[Tert-butyl(dimethyl)silyl]oxyphenyl]-pyridin-2-ylmethanone
• 化学式: C₁₈H₂₃NO₂Si
• 分子量: 313.472
• InChiKey: CFPKFANJWIEURV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴吡啶 、 ethyl (4-tert-butyldimethylsilyloxyphenyl)glyoxylate 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以50%的产率得到Di(2-pyridyl)<4-((tert-butyldimethylsilyl)oxy)phenyl>methanol
  参考文献：
  名称：

  Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives

  摘要：

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.

  DOI：

  10.1021/jo00111a038

文献信息

• Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives
  作者：Vincent Levacher、Christina Moberg

  DOI：10.1021/jo00111a038

  日期：1995.3

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.