10-[4-(dimethylamino)-N-methylanilino]-2-(4-methoxyphenyl)-1,3-diazatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-[4-(dimethylamino)-N-methylanilino]-2-(4-methoxyphenyl)-1,3-diazatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-4-one
• 化学式: C₂₇H₃₀N₄O₂
• 分子量: 442.6
• InChiKey: NZMLISDAYRBFSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  48
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL PARP INHIBITORS
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1582520A1

  公开（公告）日：2005-10-05

  A compound represented by: (wherein R1 represents H, halogen, OH, amino, or C1-4 alkyl or C1-4 alkoxy unsubstituted or substituted by 1 to 5 halogens; n represents 0 to 2; R2 and R3 each represent H, C1-6 alkyl, C2-4 alkenyl, or -L-Ar (L represents a bond or C1-6 alkylene, and Ar represents a saturated or unsaturated 5- or 6-membered ring or saturated or unsaturated 8- to 12-membered condensed-bicyclic hydrocarbon group which does not contain or contain one to three N, S, or O atoms); any group in R1 to R3 may have 1 to 3 substituents selected from group A [halogen, NO2, CN, OH, oxo, and substituted or unsubstituted amino]; X represents - (CHR4) -, - (C=NOR5) - or -C(O)-; R4 represents -NR6R7 (R6 and R7 each represent H, C1-6 alkyl, C1-6 alkylcarbonyl, or the like); R5 represents H or C1-6 alkyl; Y represents -NH- or methylene; Z represents methylene, ethylene or vinylene; and the hydrogen of Y and Z are unsubstituted or substituted by halogen, NO2, alkyl or the like) or a salt thereof, and a pharmaceutical composition containing the compound or the salt. The compound of the present invention has a poly(ADP-ribose)polymerase inhibitory effect, and is safe and advantageous for drug formulation.

  一种由以下表示的化合物：（其中R1代表H、卤素、OH、氨基或未被1至5个卤素取代或取代的C1-4烷基或C1-4烷氧基；n代表0至2；R2和R3各自代表H、C1-6烷基、C2-4烯基，或-L-Ar（L代表键或C1-6烷基，Ar代表不含或含有1至3个N、S或O原子的饱和或不饱和5-或6-成员环或饱和或不饱和8-至12-成员的环状或非环状的融合双环烃基）；R1至R3中的任何基团可能有1至3个从A组[卤素、NO2、CN、OH、氧化物或取代或未取代的氨基]中选择的取代基；X代表-（CHR4）-、-（C=NOR5）-或-C(O)-；R4代表-NR6R7（R6和R7各自代表H、C1-6烷基、C1-6烷基羰基或类似物）；R5代表H或C1-6烷基；Y代表-NH-或亚甲基；Z代表亚甲基、乙烯基或乙烯基；Y和Z的氢未被卤素、 、烷基或类似物取代或取代）或其盐，以及含有该化合物或其盐的药物组合物。本发明的化合物具有聚（ADP-核糖）聚合酶抑制作用，并且对于药物制剂是安全且有利的。
• Novel PARP inhibitor
  申请人：Shiromizu Ikuya

  公开号：US20060004028A1

  公开（公告）日：2006-01-05

  A compound represented by: or a salt thereof, and a pharmaceutical composition containing the compound or the salt, the compound having a poly (ADP-ribose)polymerase inhibitory effect, and is safe and advantageous for drug formulation.

  一种化合物，其表示为：或其盐，以及含有该化合物或盐的药物组合物，该化合物具有多聚(ADP核糖)聚合酶抑制作用，并且对于药物制剂来说是安全和有优势的。